2-(2-hydroxyethyl)quinolin-4(1H)-one | 1380391-49-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(2-hydroxyethyl)quinolin-4(1H)-one
• 英文别名: 2-(2-hydroxyethyl)-1H-quinolin-4-one
• CAS: 1380391-49-0
• 化学式: C₁₁H₁₁NO₂
• 分子量: 189.214
• InChiKey: BZPNPIIRWNYVJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (4-hydroxy-[2]quinolyl)-acetic acid ethyl ester 在 dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 以52.3%的产率得到2-(2-hydroxyethyl)quinolin-4(1H)-one
  参考文献：
  名称：

  4-Quinolones as Noncovalent Inhibitors of High Molecular Mass Penicillin-Binding Proteins

  摘要：

  Penicillin-binding proteins (PBPs) are important bacterial enzymes that carry out the final steps of bacterial cell wall assembly. Their DD-transpeptidase activity accomplishes the essential peptide cross linking step of the cell wall. To date, all attempts to discover effective inhibitors of PBPs, apart from beta-lactams, have not led to new antibiotics. Therefore, the need for new classes of efficient inhibitors of these enzymes remains. Guided by a computational fragment based docking procedure, carried out on Escherichia cob PBPS, we have designed and synthesized a series of 4-quinolones as potential inhibitors of PBPs. We describe their binding to the PBPs of E cob and Bacillus subtilis. Notably, these compounds bind quite tightly to the essential high molecular mass PBPs.

  DOI：

  10.1021/ml3001006

文献信息

• Process for Producing Olefin Copolymerization Catalyst and Process for Producing Olefin Copolymer
  申请人：NAKAHARA Shinya

  公开号：US20080227937A1

  公开（公告）日：2008-09-18

  A process for producing an olefin copolymerization catalyst, comprising the step of contacting, with one another, (A) a solid catalyst component containing a titanium atom, a magnesium atom and a halogen atom, (B) an organoaluminum compound and/or organoaluminumoxy compound, and (C) a nitrogen-containing aromatic heterocyclic compound, whose one or more carbon atoms adjacent to its nitrogen atom are linked to an electron-donating group, or a group containing an electron-donating group; and a process for producing an olefin copolymer using the an olefin copolymerization catalyst.
• US7605215B2
  申请人：——

  公开号：US7605215B2

  公开（公告）日：2009-10-20
• 4-Quinolones as Noncovalent Inhibitors of High Molecular Mass Penicillin-Binding Proteins
  作者：Abbas G. Shilabin、Liudmila Dzhekieva、Pushpa Misra、B. Jayaram、R. F. Pratt

  DOI：10.1021/ml3001006

  日期：2012.7.12

  Penicillin-binding proteins (PBPs) are important bacterial enzymes that carry out the final steps of bacterial cell wall assembly. Their DD-transpeptidase activity accomplishes the essential peptide cross linking step of the cell wall. To date, all attempts to discover effective inhibitors of PBPs, apart from beta-lactams, have not led to new antibiotics. Therefore, the need for new classes of efficient inhibitors of these enzymes remains. Guided by a computational fragment based docking procedure, carried out on Escherichia cob PBPS, we have designed and synthesized a series of 4-quinolones as potential inhibitors of PBPs. We describe their binding to the PBPs of E cob and Bacillus subtilis. Notably, these compounds bind quite tightly to the essential high molecular mass PBPs.