8-nitro-quinolin-7-ol | 208191-72-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-nitro-quinolin-7-ol
• 英文别名: 8-Nitro-chinolin-7-ol；8-nitroquinolin-7-ol
• CAS: 208191-72-4
• 化学式: C₉H₆N₂O₃
• 分子量: 190.158
• InChiKey: KPTTVUDUBTYPQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-nitro-quinolin-7-ol 在 五氯化磷 、 三氯氧磷 作用下， 生成 7-溴-8-硝基喹啉
  参考文献：
  名称：

  Kochanska; Bobranski, Chemische Berichte, 1936, vol. 69, p. 1807,1812

  摘要：

  DOI：
• 作为产物：
  描述：

  7-甲氧基-8-硝基喹啉 在 盐酸 、 水 作用下， 生成 8-nitro-quinolin-7-ol
  参考文献：
  名称：

  Kochanska; Bobranski, Chemische Berichte, 1936, vol. 69, p. 1807,1812

  摘要：

  DOI：

文献信息

• BHQ-CAGED NUCLEOTIDE PROBES PHOTOLYSABLE BY TWO-PHOTON EXCITATION
  申请人：Dore Timothy M.

  公开号：US20100048502A1

  公开（公告）日：2010-02-25

  The disclosure encompasses caged compounds such as caged nucleoside phosphoesters (caged nucleotides). In an embodiment, the caged nucleotides include compounds corresponding to those described by formula (I) that may be activated by two-photon excitation, and methods of synthesis of such compounds. 8-Bromo-7-hydroxyquinoline-caged ATP was synthesized and examined for its photochemistry as a biologically useful, temporally and spatially controlled ATP-releasing reagent. The combination of two-photon excitation hydrolysis and activation of caged ATP enables methods for finely focusing ATP activation at the sub-cellular level or to a greater depth of activation, thereby providing improved resolution of ATP-dependent processes at the cellular level.

  该披露涵盖了笼状化合物，例如笼状核苷酸磷酸酯（笼状核苷酸）。在一种实施方案中，笼状核苷酸包括与公式（I）描述的化合物相对应的化合物，可以通过双光子激发激活，并提供了这种化合物的合成方法。合成了8-溴-7-羟基喹啉笼状ATP，并对其光化学性质进行了检查，作为一种生物学上有用的、时间和空间可控的ATP释放试剂。双光子激发水解和笼状ATP的激活相结合，可以在亚细胞水平或更深的激活深度上精细地聚焦ATP的激活，从而提供了更好的细胞水平上ATP依赖过程的分辨率。
• P2X4 receptor antagonist
  申请人：NIPPON CHEMIPHAR CO., LTD

  公开号：US10633349B2

  公开（公告）日：2020-04-28

  The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R1 and R2 represent hydrogen atom and the like, or R1 and R2 bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R3 and R4 represent hydrogen atom and the like, R5 represents hydrogen atom and the like, R6 and R7 represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(═O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(═O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(═O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof, and a P2X4 receptor antagonist.

  本发明涉及一种由以下通式(I)代表的二氮卓衍生物(式中，R1和R2代表氢原子等，或R1和R2结合在一起与它们结合的苯环一起形成萘环等，R3和R4代表氢原子等，R5代表氢原子等，R6和R7代表氢原子等，X代表C、CH或N，Y代表N、NH或C(═O)、Z 代表氧原子或硫原子，A 代表苯环等，B 代表 NHC(═O) 等，D 代表原子键等、或其药理学上可接受的盐，以及 P2X4 受体拮抗剂。
• Skraup, Monatshefte fur Chemie, 1882, vol. 3, p. 551
  作者：Skraup

  DOI：——

  日期：——
• Hydroxylation of Nitroarenes with Alkyl Hydroperoxide Anions via Vicarious Nucleophilic Substitution of Hydrogen
  作者：Mieczysław Makosza、Krzysztof Sienkiewicz

  DOI：10.1021/jo970726m

  日期：1998.6.1

  Carbo- -and heterocyclic nitroarenes react with anions of tert-butyl and cumyl hydroperoxides in the presence of strong bases to form substituted o- and p-nitrophenols. The reaction usually proceeds in high yields and is of practical value as a method of synthesis and manufacturing of nitrophenols. Orientation of the hydroxylation can be controlled to a substantial extent by selection of the proper conditions. Basic mechanistic features of this process were clarified.
• P2X4 RECEPTOR ANTAGONIST
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：EP2803662B1

  公开（公告）日：2017-03-01