2-allyl-4-hydroxycyclo-2-pentenone | 61369-21-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-allyl-4-hydroxycyclo-2-pentenone
• 英文别名: 4-hydroxy-2-prop-2-enylcyclopent-2-enone；2-allyl-4-hydroxycyclopent-2-en-1-one；(RS)-3-allyl-4-oxo-2-cyclopenten-1-ol；2-Allyl-4-hydroxy-2-cyclopentenone；2-Cyclopenten-1-one, 4-hydroxy-2-(2-propenyl)-；4-hydroxy-2-prop-2-enylcyclopent-2-en-1-one
• CAS: 61369-21-9
• 化学式: C₈H₁₀O₂
• 分子量: 138.166
• InChiKey: ZSYLSLUMVHPZLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-allyl-4-hydroxycyclo-2-pentenone 在 sodium methylate 、 sodium acetate 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 3-acetoxy-4-prop-2-enylcyclopent-2-en-1-one
  参考文献：
  名称：

  Barker, Andrew J.; Pattenden, Gerald, Journal of the Chemical Society. Perkin transactions I, 1983, # 8, p. 1885 - 1891

  摘要：

  DOI：
• 作为产物：
  描述：

  4-hydroxy-5-prop-2-enylcyclopent-2-en-1-one 在 三溴乙醛 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 21.0h， 以50%的产率得到2-allyl-4-hydroxycyclo-2-pentenone
  参考文献：
  名称：

  [EN] PROSTAGLANDIN SYNTHESIS
  [FR] SYNTHESE DE LA PROSTAGLANDINE

  摘要：

  公开号：

  WO2005058812A3

文献信息

• Ester compounds pesticidal compositions containing the same and
  申请人：Sumitomo Chemical Company, Limited

  公开号：US05925676A1

  公开（公告）日：1999-07-20

  An ester compound represented by the formula ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and each represent a C.sub.1 -C.sub.6 alkyl group, or other specified groups, which may be optionally substituted with one or more halogen atoms; and R.sub.3 represents a pyrethroid acid residue (a group resulting from elimination of the carboxyl group from pyrethroid acid), and a pesticidal composition containing the ester compound as an active ingredient.

  由公式##STR1##表示的酯化合物，其中R1和R2可以相同或不同，每个代表一个C1-C6烷基团，或者其他指定的团，可任选地用一个或多个卤素原子取代；R3代表拟除虫菊酯酸残基（即从拟除虫菊酯酸中消除羧基得到的团），以及包含该酯化合物作为活性成分的杀虫剂组合物。
• SYNTHESIS OF NEW SULFUR-CONTAINING PROSTAGLANDIN I<SUB>1</SUB>
  作者：Kiyoshi Bannai、Takeshi Toru、Atsuo Hazato、Takeo Oba、Toshio Tanaka、Noriaki Okamura、Kenzo Watanabe、Seizi Kurozumi

  DOI：10.1248/cpb.30.1102

  日期：1982.3.25

  A synthesis of 4-thia-PGI1 involving addition of alkylsulfenyl chloride to allylcyclopentanol and spontaneous intramolecular cyclization is described.

  本文描述了一种合成4-thia-PGI1的方法，该方法涉及将烷基硫酰氯与烯丙基环戊醇反应，并进行自发的分子内环化。
• The Manufacture of a Homochiral 4-Silyloxycyclopentenone Intermediate for the Synthesis of Prostaglandin Analogues
  作者：Julian P. Henschke、Yuanlian Liu、Xiaohong Huang、Yungfa Chen、Dechao Meng、Lizhen Xia、Xiuqiong Wei、Aiping Xie、Danhong Li、Qiang Huang、Ting Sun、Juan Wang、Xuebin Gu、Xinyan Huang、Longhu Wang、Jun Xiao、Shenhai Qiu

  DOI：10.1021/op300188x

  日期：2012.12.21

  A process is described for the synthesis of kilogram quantities of homochiral 4-silyloxycyclopentenone (R)-1, a key intermediate useful for the synthesis of a plurality of prostaglandin analogue drugs. Cyclopentenone (R)-1 was synthesized in 14 isolated steps from furfural. Key steps in the synthesis include a Wittig reaction, Piancatelli rearrangement, and an enzymatic resolution featuring in situ

  A process is described for the synthesis of kilogram quantities of homochiral 4-silyloxycyclopentenone (R)-1, a key intermediate useful for the synthesis of a plurality of prostaglandin analogue drugs. Cyclopentenone (R)-1 was synthesized in 14 isolated steps from furfural. Key steps in the synthesis include a Wittig reaction, Piancatelli rearrangement, and an enzymatic resolution featuring in situ
• Process for preparing 4-hydroxy-2-cyclopentenones
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04608442A1

  公开（公告）日：1986-08-26

  A process for producing a compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, an alkyl group or an alkenyl group and R.sub.2 is an alkyl group, an alkenyl group or an alkynyl group, which comprises treating a compound of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are each as defined above and R is a hydrogen atom or a lower alkyl group in the presence of an acidic substance and water.

  生产化合物的方法，其分子式为：##STR1## 其中R.sub.1是氢原子、烷基或烯基，R.sub.2是烷基、烯基或炔基，包括在酸性物质和水的存在下处理以下化合物的步骤：##STR2## 其中R.sub.1和R.sub.2如上定义，R是氢原子或较低的烷基团。
• CATALYTIC ENANTIOSELECTIVE SILYLATIONS OF SUBSTRATES
  申请人：Hoveyda Amir H.

  公开号：US20090312559A1

  公开（公告）日：2009-12-17

  The present invention provides methods, compositions and systems for silylation of substrates, including direct asymmetric silylation of a substrate to provide enantiomerically enriched silylated products.

  本发明提供了用于硅烷化底物的方法、组合物和系统，包括直接不对称硅烷化底物以提供对映选择性富集的硅烷化产物。