6-乙氧基-2,4-二甲基喹啉 | 612-50-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 6-乙氧基-2,4-二甲基喹啉
• 英文名称: 2,4-dimethyl-6-ethoxy-quinoline
• 英文别名: 2,4-dimethyl-6-ethoxyquinoline；6-ethoxy-2,4-dimethylquinoline；6-ethoxy-2,4-dimethyl-quinoline；6-Aethoxy-2,4-dimethyl-chinolin
• CAS: 612-50-0
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: FSBLFAZODHUWJO-UHFFFAOYSA-N

物化性质

• 熔点：
  87-88 °C(Solv: hexane (110-54-3))
• 沸点：
  321.7±37.0 °C(Predicted)
• 密度：
  1.060±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-乙氧基-2,4-二甲基喹啉 、 对二甲氨基苯甲醛 生成 4-[trans-2-(6-ethoxy-4-methyl-[2]quinolyl)-vinyl]-N,N-dimethyl-aniline
  参考文献：
  名称：

  Studies in the Quinoline Series. I. Some 2-(p-Dialkylaminostyryl)-quinoline Derivatives¹

  摘要：

  DOI：

  10.1021/ja01220a001
• 作为产物：
  描述：

  乙氧基喹啉 以 水 为溶剂， 生成 6-乙氧基-2,4-二甲基喹啉
  参考文献：
  名称：

  A new insight into ethoxyquin fate in surface waters: Stability, direct and indirect photochemical behaviour and the identification of main products

  摘要：

  In this work, the fate of ethoxyquin (ETX), an antioxidant used as a food preservative and a pesticide, is investigated under ultraviolet and visible irradiation. The fast photolysis observed under environmentally closed conditions results in estimated degradation rates (R-ETX(d)) of 1.6 x 10(-8) and 8.7 x 10(-7) M s(-1) at pH 2.7 and 8.0, respectively. Under our experimental conditions, the polychromatic quantum yield (phi(ETX)) is evaluated to be 5.0 x 10(-3) and 1.4 x 10(-4) for the protonated and anionic forms of ETX, respectively. The effect of hydroxyl radical on ETX degradation is evaluated, and the degradation kinetics profiles suggest that transformation via hydroxyl radical can be neglected compared with direct photolysis. Structures for the main degradation products (hydrolysis, photochemical and HO center dot- mediated derivative) are proposed. The kinetic parameters are used as inputs in APEX software to model the degradation of ETX as a function of different scenarios in surface waters. Finally, the irradiation of ETX under sun-simulated conditions estimates the life of this compound to be similar to 38 s. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jphotochem.2015.06.030

文献信息

• SYNTHESIS OF PHOTOSENSITIZING DYES (II), DICYANINE A.¹
  作者：Louis A. Mikeska、Herbert L. Haller、Elliot Q. Adams

  DOI：10.1021/ja01456a038

  日期：1920.11
• Palkin; Harris, Journal of Industrial and Engineering Chemistry, 1922, vol. 14, p. 704
  作者：Palkin、Harris

  DOI：——

  日期：——
• Method of making 2,4-dialkylquinolines and of decomposing amineketone reaction products
  申请人：GOODRICH CO B F

  公开号：US02095126A1

  公开（公告）日：1937-10-05
• NEKIPELOVA T. D.; GAGARINA A. B., DOKL. AN CCCP, 1976, 231, HO 2, 392-395
  作者：NEKIPELOVA T. D.、 GAGARINA A. B.

  DOI：——

  日期：——
• [EN] INHIBITION OF BMP SIGNALING, COMPOUNDS, COMPOSITIONS AND USES THEREOF<br/>[FR] INHIBITION DE LA SIGNALISATION BMP, COMPOSÉS, COMPOSITIONS ET LEURS UTILISATIONS
  申请人：UNIV VANDERBILT

  公开号：WO2018053126A1

  公开（公告）日：2018-03-22

  Provided herein are substituted imidazo[1,2-a]pyridines useful as inhibitors of BMP signaling. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted imidazo [1,2-a] pyridines.