(4-Methoxy-3,5-dimethyl-pyridin-2-yl)-acetaldehyde | 212778-95-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4-Methoxy-3,5-dimethyl-pyridin-2-yl)-acetaldehyde
• 英文别名: 2-(4-Methoxy-3,5-dimethylpyridin-2-yl)acetaldehyde
• CAS: 212778-95-5
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: YCRKXWJVRSQVCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-氨基苯硫醇 、 (4-Methoxy-3,5-dimethyl-pyridin-2-yl)-acetaldehyde 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 反应 6.0h， 生成 2-(4-Methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-2,3-dihydro-benzothiazole
  参考文献：
  名称：

  Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric inhibitor

  摘要：

  A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/H+-ATPase. Compound 4d exhibited potent in vitro inhibitory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00334-5
• 作为产物：
  描述：

  (4-Methoxy-3,5-dimethyl-pyridin-2-yl)-acetonitrile 在 盐酸 、 manganese(IV) oxide 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 31.0h， 生成 (4-Methoxy-3,5-dimethyl-pyridin-2-yl)-acetaldehyde
  参考文献：
  名称：

  Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric inhibitor

  摘要：

  A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/H+-ATPase. Compound 4d exhibited potent in vitro inhibitory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00334-5

文献信息

• Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric inhibitor
  作者：Sung-Hwa Yoon、SeungKi Seo、YoungHee Lee、SungKwan Hwang、Dong Yeon Kim

  DOI：10.1016/s0960-894x(98)00334-5

  日期：1998.7

  A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/H+-ATPase. Compound 4d exhibited potent in vitro inhibitory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.