2-hydroxy-4-mercaptobenzaldehyde | 1246948-16-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-hydroxy-4-mercaptobenzaldehyde
• 英文别名: 2-Hydroxy-4-sulfanylbenzaldehyde；2-hydroxy-4-sulfanylbenzaldehyde
• CAS: 1246948-16-2
• 化学式: C₇H₆O₂S
• 分子量: 154.189
• InChiKey: IGUGONAKCVKCRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-hydroxy-4-mercaptobenzaldehyde 在 哌啶 、 盐酸 、 水 作用下， 以 乙醇 为溶剂， 反应 34.0h， 生成 3-(benzo[d]thiazol-2-yl)-7-mercapto-2H-chromen-2-one
  参考文献：
  名称：

  Fluorescent Coumarin Thiols Measure Biological Redox Couples

  摘要：

  In this report we present a new chemical probe, 3-HTC, that can reversibly and ratiometrically measure the thiol-disulfide equilibrium of biological systems. 3-HTC is composed of a coumarin that has a thiolate directly conjugated to its extended aromatic pi system while formation of a disulfide attenuates this conjugation. The fluorescence and absorption properties of 3-HTC are therefore very sensitive to the redox state of its thiol. 3-HTC reacts reversibly with thiols and disulfides enabling its use to measure dynamic GSH/GSSH ratios in vitro as well as to monitor the reversible redox status of whole cell lysates.

  DOI：

  10.1021/ol203105c
• 作为产物：
  描述：

  4-羟基-2-甲氧基苯甲醛 在 三乙烯二胺 、 三溴化硼 、 potassium hydroxide 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.67h， 生成 2-hydroxy-4-mercaptobenzaldehyde
  参考文献：
  名称：

  Fluorescent Coumarin Thiols Measure Biological Redox Couples

  摘要：

  In this report we present a new chemical probe, 3-HTC, that can reversibly and ratiometrically measure the thiol-disulfide equilibrium of biological systems. 3-HTC is composed of a coumarin that has a thiolate directly conjugated to its extended aromatic pi system while formation of a disulfide attenuates this conjugation. The fluorescence and absorption properties of 3-HTC are therefore very sensitive to the redox state of its thiol. 3-HTC reacts reversibly with thiols and disulfides enabling its use to measure dynamic GSH/GSSH ratios in vitro as well as to monitor the reversible redox status of whole cell lysates.

  DOI：

  10.1021/ol203105c

文献信息

• BASE GENERATOR, PHOTOSENSITIVE RESIN COMPOSITION, PATTERN FORMING MATERIAL COMPRISING THE PHOTOSENSITIVE RESIN COMPOSITION, PATTERN FORMING METHOD USING THE PHOTOSENSITIVE RESIN COMPOSITION AND PRODUCTS COMPRISING THE SAME
  申请人：Katayama Mami

  公开号：US20120070781A1

  公开（公告）日：2012-03-22

  An object of the present invention is to provide a base generator which has sensitivity and is applicable to a wide range of applications, and a photosensitive resin composition which is applicable to a wide range of applications due to the structure of a polymer precursor in which reaction into a final product is promoted by a basic substance or by heating in the presence of a basic substance. The base generator generates a base by exposure to electromagnetic radiation and heating. The photosensitive resin composition comprises a polymer precursor in which reaction into a final product is promoted by the base generator and a basic substance or by heating in the presence of a basic substance.

  本发明的目的是提供一种具有灵敏度并适用于广泛应用的基础发生器，以及一种光敏树脂组合物，由于聚合物前体的结构在碱性物质的促进下或在碱性物质存在下加热反应成最终产物，因此适用于广泛的应用范围。基础发生器通过电磁辐射和加热生成碱性物质。光敏树脂组合物包括聚合物前体，其在基础发生器和碱性物质的促进下或在碱性物质存在下加热反应成最终产物。
• 4-sulfur pentafluoride phenol compound and preparation method therefor, and preparation method for sulfur pentafluoride substituted benzopyran compound
  申请人：GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH CHINESE ACADEMY OF SCIENCES

  公开号：US10414744B2

  公开（公告）日：2019-09-17

  Provided are a 4-sulfur pentafluoride phenol compound and a preparation method therefor, and a preparation method for a sulfur pentafluoride substituted benzopyran compound. According to the present invention, sulfur pentafluoride salicylaldehyde with multiple substituent groups is synthesized through a plurality of steps by using sulfur pentafluoride phenol as a raw material, and then the sulfur pentafluoride substituted benzopyran compound is synthesized on this basis. The method is simple and convenient, and low in cost; overcomes the defects that, at present, the number of types of sulfur pentafluoride phenols is small, and the synthesis of various sulfur pentafluoride substituted benzopyran compounds cannot be met; and has wide industrial application prospects.

  本发明提供了一种 4-五氟化硫苯酚化合物及其制备方法，以及一种五氟化硫取代苯并吡喃化合物的制备方法。根据本发明，以五氟化硫苯酚为原料，通过多个步骤合成具有多个取代基的五氟化硫水杨醛，然后在此基础上合成五氟化硫取代的苯并吡喃化合物。该方法简单方便，成本低，克服了目前五氟化硫苯酚种类少，不能满足合成各种五氟化硫取代苯并吡喃化合物的缺陷，具有广泛的工业应用前景。
• 4-SULFUR PENTAFLUORIDE PHENOL COMPOUND AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR SULFUR PENTAFLUORIDE SUBSTITUTED BENZOPYRAN COMPOUND
  申请人：GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH CHINESE ACADEMY OF SCIENCES

  公开号：US20190084957A1

  公开（公告）日：2019-03-21

  Provided are a 4-sulfur pentafluoride phenol compound and a preparation method therefor, and a preparation method for a sulfur pentafluoride substituted benzopyran compound. According to the present invention, sulfur pentafluoride salicylaldehyde with multiple substituent groups is synthesized through a plurality of steps by using sulfur pentafluoride phenol as a raw material, and then the sulfur pentafluoride substituted benzopyran compound is synthesized on this basis. The method is simple and convenient, and low in cost; overcomes the defects that, at present, the number of types of sulfur pentafluoride phenols is small, and the synthesis of various sulfur pentafluoride substituted benzopyran compounds cannot be met; and has wide industrial application prospects.
• US8697332B2
  申请人：——

  公开号：US8697332B2

  公开（公告）日：2014-04-15
• [EN] BICYCLIC XANTHINE OXIDASE INHIBITORS AND METHODS OF USE<br/>[FR] INHIBITEURS DE LA XANTHINE OXYDASE BICYCLIQUE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：BAYLOR COLLEGE MEDICINE

  公开号：WO2015191640A2

  公开（公告）日：2015-12-17

  Xanthine oxidase inhibitors are provided, as well as compositions, methods for their use for treating disorders, mediated at least in part, by xanthine oxidase.