3-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-1,2,4-trioxolane | 1373139-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-1,2,4-trioxolane
• CAS: 1373139-20-8
• 化学式: C₁₇H₁₈O₅
• 分子量: 302.327
• InChiKey: VFUJYMLKNWKLNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-1,2,4-trioxolane 在 2,4,6-三甲基吡啶 、 二氯二茂钛 、 锰 、 三甲基氯硅烷 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以99%的产率得到3,3'-Dimethoxy-4,4'-bis-benzyloxy-bibenzyl
  参考文献：
  名称：

  Ti-Catalyzed Homolytic Opening of Ozonides: A Sustainable C–C Bond-Forming Reaction

  摘要：

  The unprecedented homolytic opening of ozonides promoted and catalyzed by titanocene(III) is reported. This novel reaction proceeds at room temperature under neutral, mild conditions compatible with many functional groups and provides carbon radicals suitable to form C-C bonds via both homocoupling and cross-coupling processes. The procedure has been advantageously exploited for the straightforward synthesis of the natural product brittonin A.

  DOI：

  10.1021/jo300344a
• 作为产物：
  描述：

  4-丙烯基-2-甲氧基苯苄 在 臭氧 作用下， 以 二氯甲烷 为溶剂， 以78%的产率得到3-[(3-Methoxy-4-phenylmethoxyphenyl)methyl]-1,2,4-trioxolane
  参考文献：
  名称：

  Ti-Catalyzed Homolytic Opening of Ozonides: A Sustainable C–C Bond-Forming Reaction

  摘要：

  The unprecedented homolytic opening of ozonides promoted and catalyzed by titanocene(III) is reported. This novel reaction proceeds at room temperature under neutral, mild conditions compatible with many functional groups and provides carbon radicals suitable to form C-C bonds via both homocoupling and cross-coupling processes. The procedure has been advantageously exploited for the straightforward synthesis of the natural product brittonin A.

  DOI：

  10.1021/jo300344a

文献信息

• Ti-Catalyzed Homolytic Opening of Ozonides: A Sustainable C–C Bond-Forming Reaction
  作者：Antonio Rosales、Juan Muñoz-Bascón、Cristóbal López-Sánchez、Míriam Álvarez-Corral、Manuel Muñoz-Dorado、Ignacio Rodríguez-García、J. Enrique Oltra

  DOI：10.1021/jo300344a

  日期：2012.4.20

  The unprecedented homolytic opening of ozonides promoted and catalyzed by titanocene(III) is reported. This novel reaction proceeds at room temperature under neutral, mild conditions compatible with many functional groups and provides carbon radicals suitable to form C-C bonds via both homocoupling and cross-coupling processes. The procedure has been advantageously exploited for the straightforward synthesis of the natural product brittonin A.