zolpidem hydrobromide | 299397-23-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: zolpidem hydrobromide
• 英文别名: 6-methyl-N,N-dimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide hydrobromide；N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide;hydrobromide
• CAS: 299397-23-2
• 化学式: BrH*C₁₉H₂₁N₃O
• 分子量: 388.307
• InChiKey: ZQPYVWMBTZWNRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.83
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  37.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-甲基-N,N-二甲基-2-(4-甲基苯基)-2-羟基咪唑并1,2-alpha吡啶-3-乙酰胺 在 三溴化磷 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以86%的产率得到zolpidem hydrobromide
  参考文献：
  名称：

  Process for the preparation imidazo[1,2-A]pyridine-3-acetamides

  摘要：

  本发明涉及改进的咪唑[1,2-a]吡啶-3-N,N-二烷基乙酰胺的合成，包括左西替丁酸盐。

  公开号：

  US20040010146A1

文献信息

• Modified release formulations containing a hypnotic agent
  申请人：——

  公开号：US20030054041A1

  公开（公告）日：2003-03-20

  Hypnotic pharmaceutical compositions are made from pellets and exhibit a modified release. Zolpidem or a pharmaceutically acceptable salt thereof is a typical hypnotic. The pellets are preferably spherical and exhibit a dissolution profile that includes 60% of the hypnotic agent being release from the pellet not earlier than 5 minutes from the start of a specified in vitro dissolution test. Although the modified release profile can include 50% of the hypnotic agent being released not earlier than 15 minutes after the start of the dissolution test, the pellet preferably does not contain a release rate controlling excipient or coating. Instead, microcrystalline cellulose and the active constitute the majority of the pellet, e.g. 90% or more. Spherical pellets are also made by a convenient method that is applicable to any pharmaceutically active agent.

  催眠药物组合物是由颗粒制成的，具有改变释放的特性。唑吡坦或其药学上可接受的盐是一种典型的催眠药。颗粒最好是球形的，其溶解曲线包括 60% 的催眠药在指定的体外溶解试验开始后 5 分钟内从颗粒中释放出来。虽然修正后的释放曲线可以包括 50%的催眠药在溶出试验开始后 15 分钟内释放，但颗粒最好不含控制释放速率的赋形剂或涂层。相反，微晶纤维素和活性物质占颗粒的大部分，例如 90% 或更多。球形颗粒也可通过一种适用于任何药物活性剂的便捷方法制成。
• ZOLPIDEM SALTS
  申请人：Synthon B.V.

  公开号：EP1163241B1

  公开（公告）日：2005-06-15
• MODIFIED RELEASE FORMULATIONS CONTAINING A HYPNOTIC AGENT
  申请人：Synthon B.V.

  公开号：EP1272181A2

  公开（公告）日：2003-01-08
• ZOLPIDEM TABLETS
  申请人：Synhton B.V.

  公开号：EP1948132A1

  公开（公告）日：2008-07-30
• Modified released formulations containing a hypnotic agent
  申请人：——

  公开号：US20040047908A1

  公开（公告）日：2004-03-11

  Hypnotic pharmaceutical compositions are made from pellets and exhibit a modified release. Zolpidem or a pharmaceutically acceptable salt thereof is a typical hypnotic. The pellets are preferably spherical and exhibit a dissolution profile that includes 60% of the hypnotic agent being release from the pellet not earlier than 5 minutes from the start of a specified in vitro dissolution test. Although the modified release profile can include 50% of the hypnotic agent being released not earlier than 15 minutes after the start of the dissolution test, the pellet preferably does not contain a release rate controlling excipient or coating. Instead, microcrystalline cellulose and the active constitute the majority of the pellet, e.g. 90% or more. Spherical pellets are also made by a convenient method that is applicable to any pharmaceutically active agent.