8-hydroxy-N-(2-hydroxyethyl)-2-methylquinoline-7-carboxamide | 1030596-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-hydroxy-N-(2-hydroxyethyl)-2-methylquinoline-7-carboxamide
• CAS: 1030596-36-1
• 化学式: C₁₃H₁₄N₂O₃
• 分子量: 246.266
• InChiKey: YZIHFFJVHFKJDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  82.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  8-羟基-2-甲基喹啉-7-羧酸 、 C.I.酸性橙108 以 二氯甲烷 为溶剂， 反应 4.0h， 以78.5%的产率得到8-hydroxy-N-(2-hydroxyethyl)-2-methylquinoline-7-carboxamide
  参考文献：
  名称：

  Investigating biological activity spectrum for novel quinoline analogues 2: Hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity

  摘要：

  Two series of amides based on quinoline scaffold were designed and synthesized in search of photosynthesis inhibitors. The compounds were tested for their photosynthesis-inhibiting activity against Spinacia oleracea L. and Chlorella vulgaris Beij. The compounds lipophilicity was determined by the RP-HPLC method. Several compounds showed biological activity similar or even higher than that of the standard ( DCMU). The structure-activity relationships are discussed. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.02.065

文献信息

• Investigating biological activity spectrum for novel quinoline analogues 2: Hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity
  作者：Robert Musiol、Dominik Tabak、Halina Niedbala、Barbara Podeszwa、Josef Jampilek、Katarina Kralova、Jiri Dohnal、Jacek Finster、Agnieszka Mencel、Jaroslaw Polanski

  DOI：10.1016/j.bmc.2008.02.065

  日期：2008.4

  Two series of amides based on quinoline scaffold were designed and synthesized in search of photosynthesis inhibitors. The compounds were tested for their photosynthesis-inhibiting activity against Spinacia oleracea L. and Chlorella vulgaris Beij. The compounds lipophilicity was determined by the RP-HPLC method. Several compounds showed biological activity similar or even higher than that of the standard ( DCMU). The structure-activity relationships are discussed. (c) 2008 Elsevier Ltd. All rights reserved.