6-氨基-5-beta-D-吡喃葡萄糖基氧基尿嘧啶 | 19286-37-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-氨基-5-beta-D-吡喃葡萄糖基氧基尿嘧啶
• 英文名称: 2,4,5-trihydroxy-6-aminopyrimidine 5-β-D-glucopyranoside
• 英文别名: convicine；6-amino-5-β-D-glucopyranosyloxy-1H-pyrimidine-2,4-dione；6-Amino-5-β-D-glucopyranosyloxy-1H-pyrimidin-2,4-dion；Convicin od. 6-Amino-5-(β-D-glucopyranosyloxy)-uracil；(2S,3R,4S,5S,6R)-2-(4-amino-2,6-dihydroxypyrimidin-5-yl)oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 19286-37-4
• 化学式: C₁₀H₁₅N₃O₈
• 分子量: 305.244
• InChiKey: JJWYIMQKLTVAGZ-SYCVNHKBSA-N

物化性质

• 溶解度：
  碱性溶液（微溶），DMSO（微溶）
• 密度：
  1.81±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  184
• 氢给体数：
  7
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  6-氨基-5-beta-D-吡喃葡萄糖基氧基尿嘧啶 生成 6-氨基-5-羟基-1H-嘧啶-2,4-二酮
  参考文献：
  名称：

  MARQUARDT, RONALD R.;ARBID, MAHMOUD S. S.;FROHLICH, ANDRZEJ A., J. AGR. AND FOOD CHEM., 37,(1989) N, C. 448-454

  摘要：

  DOI：
• 作为产物：
  描述：

  尿素 、 ethyl 2-cyano-2-acetate 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以65%的产率得到6-氨基-5-beta-D-吡喃葡萄糖基氧基尿嘧啶
  参考文献：
  名称：

  Kunesch, Nicole; Miet, Christine; Poisson, Jacques, Liebigs Annalen der Chemie, 1994, # 11, p. 1059 - 1064

  摘要：

  DOI：

文献信息

• Determination and stability of divicine and isouramil produced by enzymatic hydrolysis of vicine and convicine of faba bean
  作者：Marjo Pulkkinen、Xiao Zhou、Anna-Maija Lampi、Vieno Piironen

  DOI：10.1016/j.foodchem.2016.05.077

  日期：2016.12

  The aglycones of vicine and convicine, divicine and isouramil, are the causative agents of favism and, therefore, should be analysed along with vicine and convicine in research seeking to eliminate them. This study investigated the stability of the aglycones produced by hydrolysis with β-glucosidase. Reversed-phase, high-performance liquid chromatography (HPLC) with UV detection was shown to be able

  葡萄球菌和弓形虫的糖苷配基，敌草碱和异豆香精是导致favism的病原体，因此，在研究中应将其与葡萄球菌和弓形虫素一起进行分析，以消除它们。这项研究调查了由β-葡萄糖苷酶水解产生的糖苷配基的稳定性。反相高效液相色谱（UV）检测显示能够在分离的级分和蚕豆制成的提取物中以及蚕豆悬浮液中观察糖苷配基的形成和进一步的反应。在37°C的pH值为5时，Divicine和isouramil不稳定并在60分钟内几乎完全降解，在120分钟内完全降解。加入抗坏血酸钠可延缓divicine的降解。Divicine在20°C时比在37°C时更稳定。
• BIOACTIVE EXTRACT OBTAINED FROM VICIA FABA AND ITS USE IN THE TREATMENT AND/OR PREVENTION OF NEURODEGENERATIVE DISEASES
  申请人：Cacabelos Garcia, Ramon

  公开号：EP3225245A1

  公开（公告）日：2017-10-04

  The present invention provides a bioactive extract obtained from the Vicia faba pod having pro-dopaminergic, anti-inflammatory, antioxidant and neuroprotective activity, thereby improving the survival of dopaminergic neurons. Therefore, this bioproduct is proposed in the treatment and/or prevention of neurological disorders associated with a reduction in dopamine levels, such as Parkinson's Disease and other Parkinsonian syndromes of varying nature. The invention also relates to a process for obtaining said bioproduct and a pharmaceutical composition that comprises it.

  本发明提供了一种从豌豆荚中提取的生物活性提取物，该提取物具有促多巴胺能、抗炎、抗氧化和神经保护活性，从而提高多巴胺能神经元的存活率。 因此，这种生物制品可用于治疗和/或预防与多巴胺水平降低有关的神经系统疾病，如帕金森病和其他不同性质的帕金森综合症。 本发明还涉及一种获得上述生物制品的工艺以及包含该生物制品的药物组合物。
• METHODS OF PROCESSING A FAVA BEAN COMPOSITION
  申请人：Bofood Aktiebolag

  公开号：EP3750408A1

  公开（公告）日：2020-12-16

  A method of processing a fava bean composition is disclosed, the method comprising the steps of: i. providing a fava bean composition comprising fava beans, and ii. subjecting the fava bean composition to a betaglucosidase and/or at least one lactobacillus plantarum bacteria under dosage, time and temperature conditions selected so as to be sufficient to reduce the content of at least one of the compounds vicine and convicine, and preferably also at least one of the compounds divicine and isouramil, by at least 90 wt% as compared to the content of said compounds in the fava bean composition provided in step i. A fava bean composition obtained by the method as well as methods of producing food compositions using the fava bean composition and food compositions thus produced are also disclosed.

  本发明公开了一种加工蚕豆组合物的方法，该方法包括以下步骤： i. 提供由蚕豆组成的蚕豆组合物，和 ii.在选定的剂量、时间和温度条件下，将该蚕豆组合物置于倍他葡萄糖苷酶和/或至少一种植物乳杆菌的作用下，以足以将步骤 i 中提供的蚕豆组合物中的至少一种化合物维琴碱和旋覆花碱，最好还有至少一种化合物地维琴碱和异乌拉米尔的含量降低至少 90 wt%。本发明还公开了通过该方法获得的蚕豆组合物，以及使用该蚕豆组合物和由此生产的食品组合物生产食品组合物的方法。
• Process for the manufacture of a product from a plant material
  申请人：Kobenhavns Universitet

  公开号：US10292406B2

  公开（公告）日：2019-05-21

  A process for the manufacture of a product from a plant material comprising the steps of providing a disrupted plant material comprising <10% (w/w) starch and <10% (w/w) oil/lipids; adjusting the pH of the disrupted plant material to a value of pH 3.5 or below to provide an acidic suspension; heating the acidic suspension to a temperature in the range of about 50° C. to about 80° C.; isolating the product from the heated, acidic suspension. The product may be a protein product or a non-protein product. In particular, the process of the invention provides a protein product with reduced contents of non-protein components of negative nutritional value.

  一种利用植物材料制造产品的工艺，包括以下步骤：提供一种破碎的植物材料，其中淀粉含量小于10%（重量比），油脂含量小于10%（重量比）；将破碎植物材料的pH值调节到pH3.5或以下，以提供一种酸性悬浮液；将酸性悬浮液加热到约50℃至约80℃的温度范围内；从加热的酸性悬浮液中分离出产品。产品可以是蛋白质产品或非蛋白质产品。特别是，本发明的工艺提供了一种蛋白质产品，其中具有负面营养价值的非蛋白质成分含量降低。
• Extract of Vicia faba beans
  申请人：KING SAUD UNIVERSITY

  公开号：US10300100B1

  公开（公告）日：2019-05-28

  The extract of Vicia faba beans is prepared by soaking beans in distilled water overnight and then boiling in a water bath to reduce the volume of aqueous extract, which is then homogenized and filtered. The filtrate is concentrated to a smaller volume, lyophilized, and powdered. The lyophilized powder is extracted with hexane to remove oils and lipids. The oil-free lyophilized powder is dissolved in ethanol solvent and extracted for eight hours under reflux, and filtered. The volume of ethanol is reduced by a rotary evaporator, and a first off-white precipitate (sample A-1) is collected, washed with ethanol, and dried at 80° C. Mass spectrometry shows a molecular weight of 200.16447 g mol−1, and an empirical formula of C9H16N2O3 is assigned. Intraperitoneal injection of mice with 50 mg/kg of A-1 twenty minutes prior to injection with strychnine protected the mice from strychnine-induced convulsions to the same extent as phenobarbitone (phenobarbital).

  蚕豆提取物的制备方法是将蚕豆在蒸馏水中浸泡过夜，然后在水浴中煮沸，以减少水提取物的体积，然后将其均质化并过滤。滤液浓缩至较小体积，冻干并制成粉末。冻干粉用正己烷萃取，去除油脂。将不含油的冻干粉溶解在乙醇溶剂中，在回流条件下萃取 8 小时，然后过滤。用旋转蒸发仪减少乙醇的体积，收集第一种灰白色沉淀物（样品 A-1），用乙醇洗涤并在 80°C 下干燥。在给小鼠注射马钱子前 20 分钟，腹腔注射 50 毫克/千克的 A-1，可使小鼠免受马钱子引起的惊厥，其保护程度与苯巴比妥（phenobarbitone）相同。