1,2-dideoxy-D-ribo-3-heptulose | 117729-26-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2-dideoxy-D-ribo-3-heptulose
• 英文别名: (4R,5R,6R)-4,5,6,7-tetrahydroxyheptan-3-one
• CAS: 117729-26-7
• 化学式: C₇H₁₄O₅
• 分子量: 178.185
• InChiKey: KUUUPBGIMDQHPF-DSYKOEDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,2-dideoxy-6,7-isopropylidene-D-ribo-3-heptulose 以 溶剂黄146 为溶剂， 以85%的产率得到1,2-dideoxy-D-ribo-3-heptulose
  参考文献：
  名称：

  1,2-二脱氧-3-庚糖衍生物的合成

  摘要：

  摘要2,3-O-异亚丙基-d-甘油醛与三苯基（丙酰基-亚甲基）膦烷反应生成（Z）-（3）和（E）-1,2,4,5-四脱氧-6，通过色谱法分离的7-O-异亚丙基-d-甘油-庚-4-en-3-ulose（4）。用四氧化将3羟基化，得到1,2-二脱氧-6,7-O-异亚丙基-d-lyxo-（5）和-d-核糖-3-庚糖（7），将其通过柱色谱法分离。类似地，4给出了可以通过色谱法部分拆分的1,2-二脱氧-6,7-O-异亚丙基-d-阿拉伯糖-（9）和-d-木基-3-庚糖（11）的混合物。丙酮化时，5和7得到1,2-二脱氧-4,5-O-异亚丙基-d-lyxo-3-庚七-3,6-呋喃糖和3,7-脱水-1,2-二脱氧-4,5 -O-异亚丙基-β-d-核糖-3-庚-7,6-呋喃糖 而9和11的混合物给出了1,2-二脱氧-3,4：5,6-二-O-异亚丙基-β-d-阿拉伯-3-庚七-3,7-吡喃糖，1,2-二脱氧-

  DOI：

  10.1016/s0008-6215(00)90801-2

文献信息

• MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION
  申请人：Bennett C. Frank

  公开号：US20130237585A1

  公开（公告）日：2013-09-12

  Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
• Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
  申请人：Ionis Pharmaceuticals, Inc.

  公开号：US20200362353A1

  公开（公告）日：2020-11-19

  Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
• [EN] COMBINATIONS OF EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITORS AND STEROL REGULATORY ELEMENT-BINDING PROTEIN INHIBITORS FOR USES IN CANCER THERAPIES<br/>[FR] ASSOCIATIONS D'INHIBITEURS DU RÉCEPTEUR DU FACTEUR DE CROISSANCE ÉPIDERMIQUE ET D'INHIBITEURS DE PROTÉINES DE LIAISON À UN ÉLÉMENT RÉGULATEUR DE STÉROLS DESTINÉES À ÊTRE UTILISÉES DANS DES THÉRAPIES ANTICANCÉREUSES
  申请人：[en]EMORY UNIVERSITY

  公开号：WO2022120197A1

  公开（公告）日：2022-06-09

  This disclosure relates to combination therapies of epidermal growth factor receptor (EGFR) inhibitors and sterol regulatory element-binding protein (SREBP1) inhibitors for uses in cancer therapies such as lung cancer treatment. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of EGFR inhibitor in combination with a SREBP1 inhibitor to a subject in need thereof. In certain embodiments, the combination has a synergistic effect compared administration of the inhibitors individually.
• [EN] MODIFIED OLIGONUCLEOTIDES<br/>[FR] OLIGONUCLÉOTIDES MODIFIÉS
  申请人：[en]ALNYLAM PHARMACEUTICALS, INC.

  公开号：WO2022155418A1

  公开（公告）日：2022-07-21

  One aspect of the present invention relates to double-stranded RNA (dsRNA) molecules comprising a 6-methyladenine nucleobase and capable of inhibiting the expression of a target gene. Other aspects of the invention relate to pharmaceutical compositions comprising these dsRNA molecules suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA molecules, e.g., for the treatment of various disease conditions.
• Synthesis of 1,2-dideoxy-3-heptulose derivatives
  作者：Isidoro Izquierdo Cubero、Maria T. Plaza López-Espinosa

  DOI：10.1016/s0008-6215(00)90801-2

  日期：1988.2

  -isopropylidene-β- d - arabino -3-heptulo-3,7-pyranose, 1,2-dideoxy-4,5:6,7-di- O -isopropylidene- keto - d - arabino -3-heptulose, and 1,2-dideoxy-3,4:5, 7-di- O -isopropylidene-α- d - xylo -3-heptulo-3,6-furanose. Deacetonation of 5, 7, 9 , and 11 gave 1,2-dideoxy- d - lyxo -, - d - ribo , - d - arabino -, and - d - xylo -3-heptulose, respectively.

  摘要2,3-O-异亚丙基-d-甘油醛与三苯基（丙酰基-亚甲基）膦烷反应生成（Z）-（3）和（E）-1,2,4,5-四脱氧-6，通过色谱法分离的7-O-异亚丙基-d-甘油-庚-4-en-3-ulose（4）。用四氧化将3羟基化，得到1,2-二脱氧-6,7-O-异亚丙基-d-lyxo-（5）和-d-核糖-3-庚糖（7），将其通过柱色谱法分离。类似地，4给出了可以通过色谱法部分拆分的1,2-二脱氧-6,7-O-异亚丙基-d-阿拉伯糖-（9）和-d-木基-3-庚糖（11）的混合物。丙酮化时，5和7得到1,2-二脱氧-4,5-O-异亚丙基-d-lyxo-3-庚七-3,6-呋喃糖和3,7-脱水-1,2-二脱氧-4,5 -O-异亚丙基-β-d-核糖-3-庚-7,6-呋喃糖 而9和11的混合物给出了1,2-二脱氧-3,4：5,6-二-O-异亚丙基-β-d-阿拉伯-3-庚七-3,7-吡喃糖，1,2-二脱氧-