6-methyldibenzo[b,g][1,8]naphthyridin-11(6H)-one | 1367708-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methyldibenzo[b,g][1,8]naphthyridin-11(6H)-one
• 英文别名: 5-Methylquinolino[2,3-b]quinolin-12-one；5-methylquinolino[2,3-b]quinolin-12-one
• CAS: 1367708-43-7
• 化学式: C₁₇H₁₂N₂O
• 分子量: 260.295
• InChiKey: LZKDYTLKGPCAGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(trimethylsilyl)quinolin-2-yl triflate 、 邻甲氨基苯甲酸甲酯 在 cesium fluoride 作用下， 以 乙腈 为溶剂， 以32%的产率得到6-methyldibenzo[b,g][1,8]naphthyridin-11(6H)-one
  参考文献：
  名称：

  Nucleophilic addition to 2,3-pyridyne and synthesis of benzonaphthyridinones

  摘要：

  A study of the nucleophilic addition of amines to 2,3-pyridyne has been carried out. 2-Aminopyridines have been generated exclusively. A series of benzonaphthyridinones have been synthesized by reacting 2,3-pyridyne and o-aminobenzoates. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.02.002

文献信息

• Nucleophilic addition to 2,3-pyridyne and synthesis of benzonaphthyridinones
  作者：Yuesi Fang、Richard C. Larock

  DOI：10.1016/j.tet.2012.02.002

  日期：2012.4

  A study of the nucleophilic addition of amines to 2,3-pyridyne has been carried out. 2-Aminopyridines have been generated exclusively. A series of benzonaphthyridinones have been synthesized by reacting 2,3-pyridyne and o-aminobenzoates. (C) 2012 Elsevier Ltd. All rights reserved.