4-[2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)ethoxy]-2-(4-propoxyphenyl)quinoline | 1443120-77-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)ethoxy]-2-(4-propoxyphenyl)quinoline
• 英文别名: 8-[2-[2-(4-Propoxyphenyl)quinolin-4-yl]oxyethyl]-1,4-dioxa-8-azaspiro[4.5]decane；8-[2-[2-(4-propoxyphenyl)quinolin-4-yl]oxyethyl]-1,4-dioxa-8-azaspiro[4.5]decane
• CAS: 1443120-77-1
• 化学式: C₂₇H₃₂N₂O₄
• 分子量: 448.562
• InChiKey: ICLBAZDUNRCWOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  53
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)ethoxy]-2-(4-propoxyphenyl)quinoline 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 6.0h， 以40%的产率得到1-(2-{[2-(4-propoxyphenyl)quinolin-4-yl]oxy}ethyl)piperidin-4-one
  参考文献：
  名称：

  Re-evolution of the 2-Phenylquinolines: Ligand-Based Design, Synthesis, and Biological Evaluation of a Potent New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors to Combat Antimicrobial Resistance

  摘要：

  Overexpression of efflux pumps is an important mechanism by which bacteria evade the effects of antimicrobial agents that are substrates. NorA is a Staphylococcus aureus efflux pump that confers reduced susceptibility to many structurally unrelated agents, including fluoroquinolones, biocides, and dyes, resulting in a multidrug resistant (MDR) phenotype. In this work, a series of 2-phenylquinoline derivatives was designed by means of ligand-based pharmacophore modeling in an attempt to identify improved S. aureus NorA efflux pump inhibitors (EPIs). Most of the 2-phenylquinoline derivatives displayed potent EPI activity against the norA overexpressing strain SA-1199B. The antibacterial activity of ciprofloxacin, when used in combination with some of the synthesized compounds, was completely restored in SA-1199B and SA-K2378, a strain overexpressing norA from a multicopy plasmid. Compounds 3m and 3q also showed potent synergistic activity with the ethidium bromide dye in a strain overexpressing the MepA MDR efflux pump.

  DOI：

  10.1021/jm400262a
• 作为产物：
  描述：

  2-[4-(propyloxy)phenyl]quinolin-4-ol 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-[2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)ethoxy]-2-(4-propoxyphenyl)quinoline
  参考文献：
  名称：

  Re-evolution of the 2-Phenylquinolines: Ligand-Based Design, Synthesis, and Biological Evaluation of a Potent New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors to Combat Antimicrobial Resistance

  摘要：

  Overexpression of efflux pumps is an important mechanism by which bacteria evade the effects of antimicrobial agents that are substrates. NorA is a Staphylococcus aureus efflux pump that confers reduced susceptibility to many structurally unrelated agents, including fluoroquinolones, biocides, and dyes, resulting in a multidrug resistant (MDR) phenotype. In this work, a series of 2-phenylquinoline derivatives was designed by means of ligand-based pharmacophore modeling in an attempt to identify improved S. aureus NorA efflux pump inhibitors (EPIs). Most of the 2-phenylquinoline derivatives displayed potent EPI activity against the norA overexpressing strain SA-1199B. The antibacterial activity of ciprofloxacin, when used in combination with some of the synthesized compounds, was completely restored in SA-1199B and SA-K2378, a strain overexpressing norA from a multicopy plasmid. Compounds 3m and 3q also showed potent synergistic activity with the ethidium bromide dye in a strain overexpressing the MepA MDR efflux pump.

  DOI：

  10.1021/jm400262a

文献信息

• Re-evolution of the 2-Phenylquinolines: Ligand-Based Design, Synthesis, and Biological Evaluation of a Potent New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors to Combat Antimicrobial Resistance
  作者：Stefano Sabatini、Francesca Gosetto、Nunzio Iraci、Maria Letizia Barreca、Serena Massari、Luca Sancineto、Giuseppe Manfroni、Oriana Tabarrini、Mirjana Dimovska、Glenn W. Kaatz、Violetta Cecchetti

  DOI：10.1021/jm400262a

  日期：2013.6.27

  Overexpression of efflux pumps is an important mechanism by which bacteria evade the effects of antimicrobial agents that are substrates. NorA is a Staphylococcus aureus efflux pump that confers reduced susceptibility to many structurally unrelated agents, including fluoroquinolones, biocides, and dyes, resulting in a multidrug resistant (MDR) phenotype. In this work, a series of 2-phenylquinoline derivatives was designed by means of ligand-based pharmacophore modeling in an attempt to identify improved S. aureus NorA efflux pump inhibitors (EPIs). Most of the 2-phenylquinoline derivatives displayed potent EPI activity against the norA overexpressing strain SA-1199B. The antibacterial activity of ciprofloxacin, when used in combination with some of the synthesized compounds, was completely restored in SA-1199B and SA-K2378, a strain overexpressing norA from a multicopy plasmid. Compounds 3m and 3q also showed potent synergistic activity with the ethidium bromide dye in a strain overexpressing the MepA MDR efflux pump.