2-methylene-5-decynoic acid | 150254-20-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methylene-5-decynoic acid
• 英文别名: 2-Methylidenedec-5-ynoic acid
• CAS: 150254-20-9
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: VNPUNBJTAZCCDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methylene-5-decynoic acid 、 碘甲烷 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 2-methylene-5-decynoic acid methyl ester
  参考文献：
  名称：

  Activation of carbon dioxide: nickel-catalyzed electrochemical carboxylation of diynes

  摘要：

  The simultaneous activation of carbon dioxide and diynes by electrogenerated LNi(0) complexes (L = bpy, pentamethyldiethylenetriamine: PMDTA) enables the selective incorporation of one molecule of CO2 into the unsaturated systems and the preparative-scale electrosyntheses of carboxylic acids. A series of nonconjugated diynes afforded selectively linear or cyclic adducts depending on the ligand. Diynes bearing both a terminal and an internal triple bond gave exclusive CO2 incorporation into the terminal alkynyl group, regioselectively at the 2-position. The electrocarboxylation of 1,3-diynes with the Ni-PMDTA catalytic system yielded, regio- and stereoselectively, (E)-2-vinylidene-3-yne carboxylic acids in one step. The electrosyntheses were carried out in single-compartment cells fitted with a consumable magnesium anode, and utilized a catalytic amount of an air-stable Ni(II) complex as the catalyst precursor. Cyclic voltammetry studies revealed that both carbon dioxide and the diynes are able to coordinate to LNi(0)-generated species in DMF.

  DOI：

  10.1021/jo00061a038
• 作为产物：
  描述：

  1,5-癸二炔 、 草酸 在 palladium on activated charcoal 、 三苯基膦 、 1,4-双(二苯基膦)丁烷 一氧化碳 作用下， 以 乙二醇二甲醚 为溶剂， 100.0 ℃ 、4.05 MPa 条件下， 反应 24.0h， 生成 2-methylene-5-decynoic acid 、 (E)-Undec-2-en-6-ynoic acid
  参考文献：
  名称：

  Use of formic or oxalic acid for the regioselective hydrocarboxylation of alkenes and alkynes catalyzed by palladium/carbon and 1,4-bis(diphenylphosphino)butane

  摘要：

  DOI：

  10.1021/jo00069a045

文献信息

• NEW METHOD OF SYNTHESIS OF CHITOSAN DERIVATIVES AND USES THEREOF
  申请人：Bosti Trading Ltd.

  公开号：EP3865535A1

  公开（公告）日：2021-08-18

  The present invention is directed to a new cross-linked chitosan, preparations, compositions and uses thereof. In particular, the invention relates to nanoparticles and compositions thereof useful as active agents and delivery systems for at least one bioactive agent.

  本发明涉及一种新的交联壳聚糖及其制剂、组合物和用途。特别是，本发明涉及可用作活性剂和至少一种生物活性剂输送系统的纳米颗粒及其组合物。
• [EN] NEW METHOD OF SYNTHESIS OF CHITOSAN DERIVATIVES AND USES THEREOF<br/>[FR] NOUVEAU PROCÉDÉ DE SYNTHÈSE DE DÉRIVÉS DE CHITOSANE ET LEURS UTILISATIONS
  申请人：NOVOCHIZOL SA

  公开号：WO2021160667A1

  公开（公告）日：2021-08-19

  The present invention is directed to a new cross-linked chitosan, preparations, compositions and uses thereof. In particular, the invention relates to nanoparticles and compositions thereof useful as active agents and delivery systems for at least one bioactive agent.
• Use of formic or oxalic acid for the regioselective hydrocarboxylation of alkenes and alkynes catalyzed by palladium/carbon and 1,4-bis(diphenylphosphino)butane
  作者：B. El Ali、G. Vasapollo、H. Alper

  DOI：10.1021/jo00069a045

  日期：1993.8
• Activation of carbon dioxide: nickel-catalyzed electrochemical carboxylation of diynes
  作者：Sylvie Derien、Jean Claude Clinet、Elisabet Dunach、Jacques Perichon

  DOI：10.1021/jo00061a038

  日期：1993.4

  The simultaneous activation of carbon dioxide and diynes by electrogenerated LNi(0) complexes (L = bpy, pentamethyldiethylenetriamine: PMDTA) enables the selective incorporation of one molecule of CO2 into the unsaturated systems and the preparative-scale electrosyntheses of carboxylic acids. A series of nonconjugated diynes afforded selectively linear or cyclic adducts depending on the ligand. Diynes bearing both a terminal and an internal triple bond gave exclusive CO2 incorporation into the terminal alkynyl group, regioselectively at the 2-position. The electrocarboxylation of 1,3-diynes with the Ni-PMDTA catalytic system yielded, regio- and stereoselectively, (E)-2-vinylidene-3-yne carboxylic acids in one step. The electrosyntheses were carried out in single-compartment cells fitted with a consumable magnesium anode, and utilized a catalytic amount of an air-stable Ni(II) complex as the catalyst precursor. Cyclic voltammetry studies revealed that both carbon dioxide and the diynes are able to coordinate to LNi(0)-generated species in DMF.