1-methyl-3-[4(2-fluorobenzyloxy)phenyl]benzo[f]quinoline | 445466-16-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-methyl-3-[4(2-fluorobenzyloxy)phenyl]benzo[f]quinoline
• 英文别名: 3-{4-[(2-Fluorophenyl)methoxy]phenyl}-1-methylbenzo[F]quinoline；3-[4-[(2-fluorophenyl)methoxy]phenyl]-1-methylbenzo[f]quinoline
• CAS: 445466-16-0
• 化学式: C₂₇H₂₀FNO
• mdl: MFCD03034710
• 分子量: 393.46
• InChiKey: JZLHAXKFEHNRQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(4-((2-fluorobenzyl)oxy)phenyl)-N-(naphthalen-2-yl)methanimine 、 丙酮 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 1.5h， 以46%的产率得到1-methyl-3-[4(2-fluorobenzyloxy)phenyl]benzo[f]quinoline
  参考文献：
  名称：

  Synthesis of new methyl derivatives of aza-and diazaphenanthrene

  摘要：

  By condensation of acetone with 2-naphthylamine and 3-(4-fluorophenyl)-1H-pyrazole-4-, pyridine-3-, quinoline-2-, quinoline-6-carbaldehyde and 4-(2-fluorobenzyloxy) benzaldehyde new 3-aryl(heteryl)-1-methylbenzo[f]quinolines were synthesized. Reactions of acetone with 6-quinolylamine and aromatic aldehydes provided 3-aryl-1-methyl-4,7-phenanthrolines. Intermediate reaction products were isolated: 4- phenyl-or (3-pyridyl)-4-(2-naphthylamino or 6-quinolylamino)butan-2-ones.

  DOI：

  10.1134/s1070428008070178

文献信息

• Synthesis of new methyl derivatives of aza-and diazaphenanthrene
  作者：N. G. Kozlov、K. N. Gusak

  DOI：10.1134/s1070428008070178

  日期：2008.7

  By condensation of acetone with 2-naphthylamine and 3-(4-fluorophenyl)-1H-pyrazole-4-, pyridine-3-, quinoline-2-, quinoline-6-carbaldehyde and 4-(2-fluorobenzyloxy) benzaldehyde new 3-aryl(heteryl)-1-methylbenzo[f]quinolines were synthesized. Reactions of acetone with 6-quinolylamine and aromatic aldehydes provided 3-aryl-1-methyl-4,7-phenanthrolines. Intermediate reaction products were isolated: 4- phenyl-or (3-pyridyl)-4-(2-naphthylamino or 6-quinolylamino)butan-2-ones.