5-[4-(2-fluorobenzyloxy)phenyl]-1,2,3,4-tetrahydrobenzo[a]phenanthridine | 446267-02-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-[4-(2-fluorobenzyloxy)phenyl]-1,2,3,4-tetrahydrobenzo[a]phenanthridine
• 英文别名: 5-{4-[(2-Fluorophenyl)methoxy]phenyl}-1H,2H,3H,4H-benzo[A]phenanthridine；5-[4-[(2-fluorophenyl)methoxy]phenyl]-1,2,3,4-tetrahydrobenzo[a]phenanthridine
• CAS: 446267-02-3
• 化学式: C₃₀H₂₄FNO
• mdl: MFCD03308391
• 分子量: 433.525
• InChiKey: PWQBSYVECMZYJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(4-((2-fluorobenzyl)oxy)phenyl)-N-(naphthalen-2-yl)methanimine 、 环己酮 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 6.0h， 以60%的产率得到5-[4-(2-fluorobenzyloxy)phenyl]-1,2,3,4-tetrahydrobenzo[a]phenanthridine
  参考文献：
  名称：

  Condensation of fluorine-substituted benzaldehydes with amines and cyclic ketones

  摘要：

  Condensation of fluorine-containing benzaldehydes with naphthalen-2-amine or quinolin-6-amine and cyclic ketones (cyclopentanone, cyclohexanone, and 4-methylcyclohexanone) gave new fluorine-containing derivatives of cyclopenta[c]benzo[f]quinoline, benzo[a]phenanthridine, and cyclopenta[a]- and benzo[a]-[4,7]phenanthroline. Intermediate products, 2-[(fluorophenyl)(2-naphthylamino or quinolin-6-ylamino)methylidene] cyclohexanones, dihydrobenzo[f]quinolines, and dihydro-4,7-phenanthrolines, were isolated.

  DOI：

  10.1134/s1070428008060080

文献信息

• Condensation of fluorine-substituted benzaldehydes with amines and cyclic ketones
  作者：N. G. Kozlov、K. N. Gusak

  DOI：10.1134/s1070428008060080

  日期：2008.6

  Condensation of fluorine-containing benzaldehydes with naphthalen-2-amine or quinolin-6-amine and cyclic ketones (cyclopentanone, cyclohexanone, and 4-methylcyclohexanone) gave new fluorine-containing derivatives of cyclopenta[c]benzo[f]quinoline, benzo[a]phenanthridine, and cyclopenta[a]- and benzo[a]-[4,7]phenanthroline. Intermediate products, 2-[(fluorophenyl)(2-naphthylamino or quinolin-6-ylamino)methylidene] cyclohexanones, dihydrobenzo[f]quinolines, and dihydro-4,7-phenanthrolines, were isolated.