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(R)-4,5-Dimethyl-dihydro-furan-2,3-dione

中文名称
——
中文别名
——
英文名称
(R)-4,5-Dimethyl-dihydro-furan-2,3-dione
英文别名
(5R)-4,5-dimethyloxolane-2,3-dione
(R)-4,5-Dimethyl-dihydro-furan-2,3-dione化学式
CAS
——
化学式
C6H8O3
mdl
——
分子量
128.128
InChiKey
JYTLIKVWYWOQTK-SRBOSORUSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.7
  • 重原子数:
    9
  • 可旋转键数:
    0
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.67
  • 拓扑面积:
    43.4
  • 氢给体数:
    0
  • 氢受体数:
    3

反应信息

  • 作为反应物:
    描述:
    (R)-4,5-Dimethyl-dihydro-furan-2,3-dione 在 palladium on activated charcoal 吡啶氢气 作用下, 以 乙醇 为溶剂, 20.0 ℃ 、101.33 kPa 条件下, 反应 48.0h, 生成 (3S,4S,5R)-(+)-3-acetoxy-4,5-dimethyltetrahydrofuran-2-one
    参考文献:
    名称:
    Diastereo- and enantioselective synthesis of 4- and 3,4-substituted 2-acetoxy-butyrolactones
    摘要:
    An efficient asymmetric synthesis of 4-mono- and 3,4-disubstituted 2-acetoxy-butyrolactones 2 has been developed, based on a hydrazone-mediated asymmetric aldol reaction, an intramolecular lactonization and a stereoselective hydrogenation of the resulting butenolides 1. An application of this process in the synthesis of the natural hunger substance 3 (ee = 90%) is also presented, (C) 1999 Elsevier Science Ltd. All rights reserved.
    DOI:
    10.1016/s0040-4020(99)00283-5
  • 作为产物:
    参考文献:
    名称:
    Diastereo- and enantioselective synthesis of 4- and 3,4-substituted 2-acetoxy-butyrolactones
    摘要:
    An efficient asymmetric synthesis of 4-mono- and 3,4-disubstituted 2-acetoxy-butyrolactones 2 has been developed, based on a hydrazone-mediated asymmetric aldol reaction, an intramolecular lactonization and a stereoselective hydrogenation of the resulting butenolides 1. An application of this process in the synthesis of the natural hunger substance 3 (ee = 90%) is also presented, (C) 1999 Elsevier Science Ltd. All rights reserved.
    DOI:
    10.1016/s0040-4020(99)00283-5
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文献信息

  • Diastereo- and enantioselective synthesis of 4- and 3,4-substituted 2-acetoxy-butyrolactones
    作者:Dieter Enders、Hongbin Sun、Frederik R. Leusink
    DOI:10.1016/s0040-4020(99)00283-5
    日期:1999.5
    An efficient asymmetric synthesis of 4-mono- and 3,4-disubstituted 2-acetoxy-butyrolactones 2 has been developed, based on a hydrazone-mediated asymmetric aldol reaction, an intramolecular lactonization and a stereoselective hydrogenation of the resulting butenolides 1. An application of this process in the synthesis of the natural hunger substance 3 (ee = 90%) is also presented, (C) 1999 Elsevier Science Ltd. All rights reserved.
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