4-(ethoxymethyl)oxetan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 4-(ethoxymethyl)oxetan-2-one
• 英文别名: 4-(Ethoxymethyl)oxetan-2-one
• 化学式: C₆H₁₀O₃
• 分子量: 130.144
• InChiKey: ROYZTFWRTZRWNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙基缩水甘油基醚 、 一氧化碳 在 锰 、 N,N′-bis(3,5-di-tert-butylsalicylidene)phenylenediimine chromium(III) chloride 、 cobalt(II) bromide 作用下， 以 四氢呋喃 为溶剂， 50.0 ℃ 、2.0 MPa 条件下， 生成 4-(ethoxymethyl)oxetan-2-one
  参考文献：
  名称：

  以无机盐为催化物种前体的环氧化物羰基扩环反应生成β-内酯

  摘要：

  开发了一种从廉价、空气稳定的溴化钴原位生成低价钴物种的策略，用于环氧化物羰基化扩环生成 β-内酯产品，收率中等至极佳。这项工作也代表了大气 CO2 压力下环氧化物羰基化的罕见例子。

  DOI：

  10.1002/ejic.202200496

文献信息

• COMPOSITIONS AND METHODS FOR SELECTIVE CARBONYLATION OF HETEROCYCLIC COMPOUNDS
  申请人：Massachusetts Institute of Technology

  公开号：US20200164353A1

  公开（公告）日：2020-05-28

  Compositions comprising metal organic frameworks and related methods and uses are generally provided, including use in selective carbonylation of heterocyclic compounds.

  通常提供了包含金属有机框架的组合物、相关方法和用途，包括在杂环化合物的选择性羰基化中使用。
• ISOCYANATES, DERIVATIVES, AND PROCESSES FOR PRODUCING THE SAME
  申请人：Novomer, Inc.

  公开号：US20200331876A1

  公开（公告）日：2020-10-22

  The present invention is directed to processes for producing isocyanates and isocyanate derivatives from epoxide and carbon monoxide reagents. In preferred embodiments, the processes include a step for providing carbonylation of an epoxide reagent with a carbon monoxide reagent to produce a beta-lactone intermediate. In certain preferred embodiments, further carbonylation of a beta-lactone intermediate produces a succinic anhydride intermediate. The processes of the present invention include steps for rearranging beta-lactone intermediates and/or succinic anhydride intermediates to produce isocyanate products and/or isocyanate derivatives. In certain preferred embodiments, the isocyanate products may be copolymerized with polyol oligomers to provide polyurethane products.
• POLYLACTONE FOAMS AND METHODS OF MAKING THE SAME
  申请人：Novomer, Inc.

  公开号：US20210324168A1

  公开（公告）日：2021-10-21

  The present invention is directed to compositions comprising polylactone melt, extrudate, and processes for producing a foam. In exemplary embodiments of the present invention, the processes comprise: heating a polylactone composition containing a biobased polylactone in a reaction vessel; and subjecting the polylactone composition to molding to give a foamed structure.
• Carbonylative Ring Expansion of Epoxides to β‐Lactones Using Inorganic Salt as Catalytic Species Precursor
  作者：L. He、J.‐C. Yang、T.‐T. Song、Y. Liu、X.‐B. Lu

  DOI：10.1002/ejic.202200496

  日期：2022.12.16

  cobalt bromide was developed for carbonylative ring expansion of epoxides to β-lactone products in moderate to excellent yields. This work also represents a rare example of epoxide carbonylation under atmospheric CO pressure.

  开发了一种从廉价、空气稳定的溴化钴原位生成低价钴物种的策略，用于环氧化物羰基化扩环生成 β-内酯产品，收率中等至极佳。这项工作也代表了大气 CO2 压力下环氧化物羰基化的罕见例子。