2-Tert-butyl-6-methoxy-8-nitro-4-phenylquinoline | 1201066-14-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-Tert-butyl-6-methoxy-8-nitro-4-phenylquinoline
• CAS: 1201066-14-9
• 化学式: C₂₀H₂₀N₂O₃
• 分子量: 336.39
• InChiKey: YJAZXKQBCSFFDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  67.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  特戊醛 、 苯乙炔 、 2-硝基-4-甲氧基苯胺 在 氧气 作用下， 反应 6.0h， 以41%的产率得到2-Tert-butyl-6-methoxy-8-nitro-4-phenylquinoline
  参考文献：
  名称：

  A new process of multicomponent Povarov reaction–aerobic dehydrogenation: synthesis of polysubstituted quinolines

  摘要：

  A new domino process of three-component Povarov reaction and aerobic dehydrogenation was developed toward the synthesis of polysubstituted quinolines. 2,4-Disubstituted-8-nitroquinolines, which are important precursors for the synthesis of antimalarial primaquine drug-like molecules, were prepared conveniently by this method in moderate to good yields. Bronsted acid (HClO(4))-modified montmorillonite was found to be a crucial catalyst in promoting the procedure. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.125

文献信息

• A new process of multicomponent Povarov reaction–aerobic dehydrogenation: synthesis of polysubstituted quinolines
  作者：Sankar K. Guchhait、Khyati Jadeja、Chetna Madaan

  DOI：10.1016/j.tetlet.2009.09.125

  日期：2009.12

  A new domino process of three-component Povarov reaction and aerobic dehydrogenation was developed toward the synthesis of polysubstituted quinolines. 2,4-Disubstituted-8-nitroquinolines, which are important precursors for the synthesis of antimalarial primaquine drug-like molecules, were prepared conveniently by this method in moderate to good yields. Bronsted acid (HClO(4))-modified montmorillonite was found to be a crucial catalyst in promoting the procedure. (C) 2009 Elsevier Ltd. All rights reserved.