6-[4-[N-(2-dimethylaminoethyl)-N-methylaminocarbonyloxy]-2-methoxyphenyl]-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline | 1027100-68-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[4-[N-(2-dimethylaminoethyl)-N-methylaminocarbonyloxy]-2-methoxyphenyl]-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline
• 英文别名: [4-[5-[(5-fluoro-2-methylphenoxy)methyl]-2,2,4-trimethyl-1H-quinolin-6-yl]-3-methoxyphenyl] N-[2-(dimethylamino)ethyl]-N-methylcarbamate
• CAS: 1027100-68-0
• 化学式: C₃₃H₄₀FN₃O₄
• 分子量: 561.697
• InChiKey: ZUFHNKZIUUTCQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  41
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  63.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  SA22313 、 N,N,N'-三甲基乙二胺 、 N,N'-羰基二咪唑 在 4-二甲氨基吡啶 silica gel 、 ethyl acetate n-hexane 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以to give the titled compound (10.0 mg) as a colorless amorphous product的产率得到6-[4-[N-(2-dimethylaminoethyl)-N-methylaminocarbonyloxy]-2-methoxyphenyl]-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline
  参考文献：
  名称：

  Method for preventing or treating a disease related to the glucocorticoid receptor

  摘要：

  一种预防或治疗与糖皮质激素受体相关的疾病的方法，涉及给予1,2-羟基喹啉化合物的药理有效剂量。

  公开号：

  US20110275620A1

文献信息

• Method for preventing or treating a disease related to the glucocorticoid receptor
  申请人：Matsuda Mamoru

  公开号：US20110275620A1

  公开（公告）日：2011-11-10

  A method for preventing or treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-hydroquinoline compound.

  一种预防或治疗与糖皮质激素受体相关的疾病的方法，涉及给予1,2-羟基喹啉化合物的药理有效剂量。
• GLUCOCORTICOID RECEPTOR AGONIST COMPRISING 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVES HAVING SUBSTITUTED OXY GROUP
  申请人：Kato Masatomo

  公开号：US20110118260A1

  公开（公告）日：2011-05-19

  The present invention is related to glucocorticoid receptor agonists comprised of a compound represented by formula (1) which is 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivative or a salt thereof and novel pharmacological effects of the glucocorticoid receptor agonists. In the formula (1), R 1 represents formula (2a), (3a), (4a) or (5a); R 2 represents —(CO)—R8, —(CO)O—R9, or the like; R 2 —O— is substituted at the 4- or -5-position of benzene ring A; R 3 represents a lower alkyl group; R 4 , R 5 , R 6 or R 7 represents a halogen atom, a lower alkyl group which may have a substituent, or the like; m, n, p or q represents 0, 1 or the like; R 8 , R 9 or the like represents a lower alkyl group which may have a substituent, a lower alkenyl group, or the like.

  本发明涉及由式（1）表示的化合物组成的糖皮质激素受体激动剂或其盐，并且涉及糖皮质激素受体激动剂的新的药理作用。在式（1）中，R1表示式（2a）、（3a）、（4a）或（5a）；R2表示—（CO）—R8、—（CO）O—R9或类似物；R2—O—在苯环A的4-或5-位上被取代；R3表示较低的烷基；R4、R5、R6或R7表示卤原子、可能具有取代基的较低的烷基或类似物；m、n、p或q表示0、1或类似物；R8、R9或类似物表示可能具有取代基的较低的烷基、较低的烯基或类似物。
• NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED PHENYLCHALCOGENO LOWER ALKYL GROUP AND ESTER-INTRODUCED PHENYL GROUP AS SUBSTITUENTS
  申请人：Santen Pharmaceutical Co., Ltd

  公开号：EP2085387B1

  公开（公告）日：2013-04-10
• GLUCOCORTICOID RECEPTOR AGONIST COMPOSED OF 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED OXY GROUP
  申请人：AYUMI Pharmaceutical Corporation

  公开号：EP2319835B1

  公开（公告）日：2016-04-13
• NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED PHENYLCHALCOGENO LOWER ALKYL GROUP AND ESTER- INTRODUCED PHENYL GROUP AS SUBSTITUENTS
  申请人：Matsuda Mamoru

  公开号：US20100056504A1

  公开（公告）日：2010-03-04

  The compounds represented in general formula (1) and a salt thereof are useful for glucocorticoid receptor modulator. The R 1 represents a hydrogen atom or a lower alkyl group; R 2 represents a hydrogen atom or a lower alkyl group; R 3 and R 4 may be the same or different and represent a hydrogen atom or a lower alkyl group; R 5 represents a hydrogen atom or a lower alkyl group; R 6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group or a nitro group; X represents —C(O)—, —C(O)NR 8 —, —S(O) 2 — and the like; R 7 and/or R 8 may be the same or different and represent a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, a lower alkoxy group which may have a substituent and the like; Y represents a lower alkylene group; Z represents a chalcogen atom; and P represents 0, 1, 2 or 3.