(Z)-1,1,1-trifluoro-2-decen-4-ol | 94793-00-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-1,1,1-trifluoro-2-decen-4-ol
• 英文别名: (Z)-1,1,1-trifluorodec-2-en-4-ol
• CAS: 94793-00-7
• 化学式: C₁₀H₁₇F₃O
• 分子量: 210.24
• InChiKey: HRAIBOVYRMCRNB-FPLPWBNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,1,1-trifluoro-2-decyn-4-ol 在 cis-[PdCl₂(CN(t-Bu))₂] 、 六正丁基二锡 、 盐酸 、 水 、 碳酸氢钠 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 乙腈 、 水 为溶剂， 以0.25 mmol的产率得到(Z)-1,1,1-trifluoro-2-decen-4-ol
  参考文献：
  名称：

  An Efficient Protocol for the Stereoselective Construction of Multisubstituted Fluorine-Containing Alkenes. A Palladium-Catalyzed Bisstannylation of Fluorinated Internal Alkynes

  摘要：

  On treatment of various fluorinated internal alkynes with 1.2 equiv of hexabutylditin under the influence of 2.5 mol % of Pd(t-BuNC)(2)Cl(2) in THF at room temperature for 4 h, the bisstannylation proceeded smoothly to afford the corresponding bisstannylaled cis-adducts in high yields. Thus obtained adducts were subjected to the Stille cross-coupling reaction to give the corresponding tetrasubstituted fluorine-containing alkenes with defined stereochemistry in good yields.

  DOI：

  10.1021/jo9017028

文献信息

• Hydrometallation of 1-alkyl-3-trifluoromethyl propargyl alcohols
  作者：Yuji Hanzawa、Kei-ichi Kawagoe、Naomi Tanahashi、Yoshiro Kobayashi

  DOI：10.1016/s0040-4039(01)81509-4

  日期：——
• HANZAWA, YUJI;KAWAGOE, KEI-ICHI;TANAHASHI, NAOMI;KOBAYASHI, YOSHIRO, TETRAHEDRON LETT., 1984, 25, N 42, 4749-4752
  作者：HANZAWA, YUJI、KAWAGOE, KEI-ICHI、TANAHASHI, NAOMI、KOBAYASHI, YOSHIRO

  DOI：——

  日期：——
• An Efficient Protocol for the Stereoselective Construction of Multisubstituted Fluorine-Containing Alkenes. A Palladium-Catalyzed Bisstannylation of Fluorinated Internal Alkynes
  作者：Tsutomu Konno、Ryoko Kinugawa、Atsunori Morigaki、Takashi Ishihara

  DOI：10.1021/jo9017028

  日期：2009.11.6

  On treatment of various fluorinated internal alkynes with 1.2 equiv of hexabutylditin under the influence of 2.5 mol % of Pd(t-BuNC)(2)Cl(2) in THF at room temperature for 4 h, the bisstannylation proceeded smoothly to afford the corresponding bisstannylaled cis-adducts in high yields. Thus obtained adducts were subjected to the Stille cross-coupling reaction to give the corresponding tetrasubstituted fluorine-containing alkenes with defined stereochemistry in good yields.