2'-bromo-4,4'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde | 1459238-33-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2'-bromo-4,4'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde
• 英文别名: 2-(2-Bromo-4-methoxyphenyl)-5-methoxybenzaldehyde；2-(2-bromo-4-methoxyphenyl)-5-methoxybenzaldehyde
• CAS: 1459238-33-5
• 化学式: C₁₅H₁₃BrO₃
• 分子量: 321.17
• InChiKey: WUPXOUIPPIZSCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2'-bromo-4,4'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde 在 吡啶 、 potassium permanganate 、 草酰氯 、 噻吩-2-甲酸亚铜(I) 、 四甲基乙二胺 、 三溴化硼 、 caesium carbonate 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 、 水 为溶剂， 300.0 ℃ 、1.72 MPa 条件下， 反应 2.17h， 生成 尿石素A
  参考文献：
  名称：

  Cu(I)-mediated lactone formation in subcritical water: a benign synthesis of benzopyranones and urolithins A–C

  摘要：

  Benzopyranones were successfully synthesized using Cu(I)-mediated C-O bond formation in subcritical water. A number of benzopyranone derivatives including polymethoxy benzopyranones, benzopyranopyridones, cbromenoindolones, and furochromenones were synthesized in satisfactory yield. This methodology was further applied to synthesize the intestinal microbial metabolites, urolithins A, B, and C, which were found to exhibit potent antioxidant activity. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.08.045
• 作为产物：
  描述：

  间溴苯甲醚 在 bis-triphenylphosphine-palladium(II) chloride 、 碘 、 silver trifluoroacetate 、 potassium carbonate 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 3.0h， 生成 2'-bromo-4,4'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde
  参考文献：
  名称：

  Cu(I)-mediated lactone formation in subcritical water: a benign synthesis of benzopyranones and urolithins A–C

  摘要：

  Benzopyranones were successfully synthesized using Cu(I)-mediated C-O bond formation in subcritical water. A number of benzopyranone derivatives including polymethoxy benzopyranones, benzopyranopyridones, cbromenoindolones, and furochromenones were synthesized in satisfactory yield. This methodology was further applied to synthesize the intestinal microbial metabolites, urolithins A, B, and C, which were found to exhibit potent antioxidant activity. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.08.045

文献信息

• Tetrahedron 2013, 69, 9277-9283
  作者：

  DOI：——

  日期：——
• Cu(I)-mediated lactone formation in subcritical water: a benign synthesis of benzopyranones and urolithins A–C
  作者：Prattya Nealmongkol、Kassrin Tangdenpaisal、Somkid Sitthimonchai、Somsak Ruchirawat、Nopporn Thasana

  DOI：10.1016/j.tet.2013.08.045

  日期：2013.11

  Benzopyranones were successfully synthesized using Cu(I)-mediated C-O bond formation in subcritical water. A number of benzopyranone derivatives including polymethoxy benzopyranones, benzopyranopyridones, cbromenoindolones, and furochromenones were synthesized in satisfactory yield. This methodology was further applied to synthesize the intestinal microbial metabolites, urolithins A, B, and C, which were found to exhibit potent antioxidant activity. (C) 2013 Elsevier Ltd. All rights reserved.