6-甲氧基双环[4.1.0]庚烷 | 34737-44-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-甲氧基双环[4.1.0]庚烷
• 英文名称: 1-Methoxy-norcaran
• 英文别名: 1-Methoxy-bicyclo[4.1.0]heptan；1-Methoxybicyclo[4.1.0]heptane
• CAS: 34737-44-5
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: YIIOFLGQQRENNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-甲氧基双环[4.1.0]庚烷 在 4,4'-联苯甲腈 、 铜 、 锌 作用下， 以 甲醇 为溶剂， 生成 1-Methoxybicyclo[5.1.0]octane
  参考文献：
  名称：

  Ring expansions via photoinduced single electron transfer promoted opening of cyclopropyl ethers

  摘要：

  DOI：

  10.1021/jo00258a044
• 作为产物：
  描述：

  二碘甲烷 、 1-甲氧基环己烯 在 铜 、 锌 作用下， 以64%的产率得到6-甲氧基双环[4.1.0]庚烷
  参考文献：
  名称：

  Ring expansions via photoinduced single electron transfer promoted opening of cyclopropyl ethers

  摘要：

  DOI：

  10.1021/jo00258a044

文献信息

• Reaction of enol ethers with zinc carbenoid reagents. Cyclopropanation and subsequent isomerization to allylic ethers
  作者：Ilhyong Ryu、Tomoyuki Aya、Shoji Otani、Shinji Murai、Noboru Sonoda

  DOI：10.1016/0022-328x(87)80300-5

  日期：1987.4

  reactions of enol ethers (ROCC, R = alkyl, silyl) with zinc carbenoid reagents were found to give allylic ethers in several cases along with the expected cyclopropyl ethers. The ratio of these two products was highly dependent on the concentration of the reaction mixture. Thus, the selective formation of each product was conveniently attained by merely changing the amounts of the solvent used. Zinc iodide

  发现烯醇醚（ROCC，R =烷基，甲硅烷基）与类胡萝卜素锌试剂的反应在某些情况下与预期的环丙基醚一起生成烯丙基醚。这两种产物的比例高度依赖于反应混合物的浓度。因此，通过仅改变所用溶剂的量就可以方便地实现每种产物的选择性形成。该反应的副产物碘化锌在本发明的环丙基至烯丙基重排中起关键作用。提出了开环的离子中间体。
• Relative rates and stereochemistry of the iodomethylzinc iodide methylenation of some hydroxy- and methoxy-substituted cyclic olefins
  作者：James H. H. Chan、Bruce Rickborn

  DOI：10.1021/ja01025a028

  日期：1968.11
• RYU H. HYONG; AYA TOMOYUKI; OTANI SHOJI; MURAI SHINJI; SONODA NOBORU, J. ORGANOMET. CHEM., 321,(1987) N 3, 279-290
  作者：RYU H. HYONG、 AYA TOMOYUKI、 OTANI SHOJI、 MURAI SHINJI、 SONODA NOBORU

  DOI：——

  日期：——
• GASSMAN, P. G.;BURNS, S. J., J. ORG. CHEM., 53,(1988) N 23, C. 5576-5578
  作者：GASSMAN, P. G.、BURNS, S. J.

  DOI：——

  日期：——
• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.