2-β-D-glucopyranosyloxy-5-hydroxy-benzoic acid ethyl ester | 108975-20-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-β-D-glucopyranosyloxy-5-hydroxy-benzoic acid ethyl ester
• 英文别名: 2-β-D-Glucopyranosyloxy-5-hydroxy-benzoesaeure-aethylester；ethyl 5-hydroxy-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybenzoate
• CAS: 108975-20-8
• 化学式: C₁₅H₂₀O₉
• 分子量: 344.318
• InChiKey: FTMMEVFXCMIPBB-ZHZXCYKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  5-O-Acetylgentisinsaeure 在 喹啉 、 乙醚 、 乙醇 、 sodium ethanolate 、 silver(l) oxide 作用下， 生成 2-β-D-glucopyranosyloxy-5-hydroxy-benzoic acid ethyl ester
  参考文献：
  名称：

  Über 2- und 5-β-D-Glucopyranoside verschiedener Gentisinsäureester. II. Mitteilung „Über Phenolglykoside”

  摘要：

  DOI：

  10.1002/ardp.19582910604

文献信息

• PHARMACEUTICAL PREPARATION FOR EXTERNAL APPLICATION TO SKIN COMPRISING PHOSPHORYLATED SUGAR
  申请人：Ezaki Glico Co., Ltd.

  公开号：EP1932514A1

  公开（公告）日：2008-06-18

  Provided is an external preparation for skin, comprising a phosphorylated saccharide. The phosphorylated saccharide may be an inorganic salt of a phosphorylated saccharide. The phosphorylated saccharide may be a calcium, magnesium, potassium, zinc, iron or sodium salt. Also provided is an external preparation for skin, comprising a phosphorylated saccharide and a second component, wherein the second component is selected from the group consisting of moisturizing agents, whitening components, ultraviolet absorbents, anti-inflammatory agents, cell-activating agents and antioxidants. The moisturizing agent may be ascorbic acid or an ascorbic acid derivative.

  本文提供了一种皮肤外用制剂，其中包含一种磷酸化糖。磷酸化糖可以是磷酸化糖的无机盐。磷酸化糖可以是钙、镁、钾、锌、铁或钠盐。还提供了一种皮肤外用制剂，包括磷酸化糖和第二种成分，其中第二种成分选自保湿剂、美白成分、紫外线吸收剂、消炎剂、细胞活化剂和抗氧化剂组成的组。保湿剂可以是抗坏血酸或抗坏血酸衍生物。
• Skin whitening agents containing glycosides
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0649648B1

  公开（公告）日：2001-09-19
• External Preparation for Skin Containing a Phosphorlated Saccharide
  申请人：Tanaka Tomoko

  公开号：US20080274068A1

  公开（公告）日：2008-11-06

  Provided is an external preparation for skin, comprising a phosphorylated saccharide. The phosphorylated saccharide may be an inorganic salt of a phosphorylated saccharide. The phosphorylated saccharide may be a calcium, magnesium, potassium, zinc, iron or sodium salt. Also provided is an external preparation for skin, comprising a phosphorylated saccharide and a second component, wherein the second component is selected from the group consisting of moisturizing agents, whitening components, ultraviolet absorbents, anti-inflammatory agents, cell-activating agents and antioxidants. The moisturizing agent may be ascorbic acid or an ascorbic acid derivative.
• EXTERNAL PREPARATION FOR SKIN CONTAINING A PHOSPHORYLATED SACCHARIDE
  申请人：EZAKI GLICO CO., LTD.

  公开号：US20140023602A1

  公开（公告）日：2014-01-23

  Provided is an external preparation for skin, comprising a phosphorylated saccharide. The phosphorylated saccharide may be an inorganic salt of a phosphorylated saccharide. The phosphorylated saccharide may be a calcium, magnesium, potassium, zinc, iron or sodium salt. Also provided is an external preparation for skin, comprising a phosphorylated saccharide and a second component, wherein the second component is selected from the group consisting of moisturizing agents, whitening components, ultraviolet absorbents, anti-inflammatory agents, cell-activating agents and antioxidants. The moisturizing agent may be ascorbic acid or an ascorbic acid derivative.