7,8-二氯-9-甲基吡啶并[3,4-b]吲哚 | 156312-10-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 7,8-二氯-9-甲基吡啶并[3,4-b]吲哚
• 英文名称: bauerine B
• 英文别名: 7,8-dichloro-9-methylpyrido[3,4-b]indole
• CAS: 156312-10-6
• 化学式: C₁₂H₈Cl₂N₂
• 分子量: 251.115
• InChiKey: XGTYSLIGRKUXED-UHFFFAOYSA-N

物化性质

• 熔点：
  148 °C
• 沸点：
  431.3±45.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氧代哌啶-3-羧酸 在 盐酸 、 甲酸 、 硼烷四氢呋喃络合物 、 potassium tert-butylate 、 2,3-二氯-5,6-二氰基-1,4-苯醌 、 sodium nitrite 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 二甲基亚砜 为溶剂， 反应 70.67h， 生成 7,8-二氯-9-甲基吡啶并[3,4-b]吲哚
  参考文献：
  名称：

  Total Syntheses of the Chlorinated β‐Carboline Alkaloids Bauerine A, B, and C

  摘要：

  DOI：

  10.1080/00397910701226228

文献信息

• Carbolines, Part VI. First Total Synthesis of Bauerine B and Its Demethyl Analogue
  作者：Patrick Rocca、Francis Marsais、Alain Godard、Guy Quéguiner

  DOI：10.1080/00397919508011420

  日期：1995.10

  Abstract Short and convergent syntheses of Bauerine B and its demethyl analogue are reported. The approach is based on a convergent methodology which involves such reactions as metalation, heteroring cross-coupling and cyclization.

  摘要 报道了鲍瑞林 B 及其去甲基类似物的短程收敛合成。该方法基于收敛方法，该方法涉及诸如金属化、杂环交叉偶联和环化等反应。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Extracts of Curcuma and Methods of Use Thereof
  申请人：Alberte Randall S.

  公开号：US20100098788A1

  公开（公告）日：2010-04-22

  The present invention relates in part to turmeric extracts that are useful for treating or preventing neurodegenerative disorders. Another aspect of the invention relates in part to turmeric extracts that are useful for treating or preventing inflammatory disorders. In some embodiments, the extracts comprise at least one compound selected from the group consisting of 25 to 500 μg bamosamine, 25 to 750 μg echinaxanthol, 100 to 3,000 μg bisdemethoxycurcumin, 50 to 500 μg daphniyunnine E and 500 to 75,000 μg curcumin per 100 mg of extract. Another aspect of the invention relates to pharmaceutical compositions comprising the aforementioned extracts. Another aspect of the invention relates to methods of treating or preventing neurodegenerative disorders comprising administering to a subject in need thereof an effective amount of the aforementioned extracts or compositions. Another aspect of the invention relates to methods of making the aforementioned extracts.
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：ENEVOLV, INC.

  公开号：US20160186168A1

  公开（公告）日：2016-06-30

  The present disclosure provides compositions and methods for genomic engineering.
• US9944925B2
  申请人：——

  公开号：US9944925B2

  公开（公告）日：2018-04-17