1-Ethyl-6,8-difluoro-1,4-dihydro-7-(2,7-diazaspiro[4.4]non-2-yl)-4-oxo-3-quinolinecarboxylic acid | 91188-25-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(2,7-diazaspiro[4.4]non-2-yl)-4-oxo-3-quinolinecarboxylic acid
• 英文别名: 7-(3,8-Diazaspiro[4.4]nonan-8-yl)-1-ethyl-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid；7-(2,7-diazaspiro[4.4]nonan-2-yl)-1-ethyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
• CAS: 91188-25-9
• 化学式: C₁₉H₂₁F₂N₃O₃
• 分子量: 377.391
• InChiKey: NVVIXKGACSGLKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  72.9
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1-乙基-6,7,8-三氟-1,4-二氢-4-氧代喹啉-2-羧酸 、 2,7-二氮杂螺[4.4]壬烷 以 乙腈 为溶剂， 反应 49.5h， 以to afford 1.17 g of the title compound, mp 234°-240° C. (dec)的产率得到1-Ethyl-6,8-difluoro-1,4-dihydro-7-(2,7-diazaspiro[4.4]non-2-yl)-4-oxo-3-quinolinecarboxylic acid
  参考文献：
  名称：

  Antibacterial agents

  摘要：

  本文介绍了新型萘啶基、喹啉基和苯并噁嗪基羧酸作为抗菌剂，并描述了它们的制造、配方和用于治疗细菌感染的方法，包括用于制造抗菌剂的某些新型中间体的描述。

  公开号：

  US04638067A1

文献信息

• 7-Substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0153163A2

  公开（公告）日：1985-08-28

  Compound of formula where X is CH, CCl, CF, C-OH, CO-alkyl having from one to three carbons, C-NH-alkyl having from one to three carbons, or N; Y is H, F, Cl or Br; R2 is alkyl having from one to four carbon atoms, vinyl, haloalkyl, or hydroxyalkyl having from two to four carbon atoms or cycloalkyl having three to six carbon atoms. Also described are methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufac- ture of the compounds. The compounds are useful as antibacterial agents.

  式中 X 为 CH、CCl、CF、C-OH、具有一至三个碳原子的 CO-烷基、具有一至三个碳原子的 C-NH- 烷基或 N；Y 为 H、F、Cl 或 Br；R2 为具有一至四个碳原子的烷基、具有二至四个碳原子的乙烯基、卤代烷基或羟基烷基或具有三至六个碳原子的环烷基。 还描述了其制造、配制和用于治疗细菌感染的方法，包括描述了用于制造这些化合物的某些新型中间体。 这些化合物可用作抗菌剂。
• Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships
  作者：Townley P. Culbertson、Joseph P. Sanchez、Laura Gambino、Josephine A. Sesnie

  DOI：10.1021/jm00170a035

  日期：1990.8

  A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspiro[4.4]nonane (4b), 1,7-diazaspiro[4.4]nonane (5a), or 2,8-diazaspiro[5.5]undecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues. Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.
• CULBERTSON, TOWNLEY P.;SANCHEZ, JOSEPH P.;GAMBINO, LAURA;SESNIE, JOSEPHIN+, J. MED. CHEM., 33,(1990) N, C. 2270-2275
  作者：CULBERTSON, TOWNLEY P.、SANCHEZ, JOSEPH P.、GAMBINO, LAURA、SESNIE, JOSEPHIN+

  DOI：——

  日期：——
• US4638067A
  申请人：——

  公开号：US4638067A

  公开（公告）日：1987-01-20
• US4665079A
  申请人：——

  公开号：US4665079A

  公开（公告）日：1987-05-12