Manalpha1-3Manbeta1-4-GlcNAcbeta1-4GlcNAcbeta

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Manalpha1-3Manbeta1-4-GlcNAcbeta1-4GlcNAcbeta
• 英文别名: N-[(2R,3R,4R,5S,6R)-5-[(2S,3R,4R,5S,6R)-3-acetamido-5-[(2S,3S,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• 化学式: C₂₈H₄₈N₂O₂₁
• 分子量: 748.69
• InChiKey: PXIZVBXXKZFZSG-BHEKIWMKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.5
• 重原子数：
  51
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  366
• 氢给体数：
  14
• 氢受体数：
  21

反应信息

• 作为产物：
  描述：

  在 palladium on activated charcoal sodium methylate 、 氢气 作用下， 以 甲醇 、 水 为溶剂， 反应 24.0h， 生成 Manalpha1-3Manbeta1-4-GlcNAcbeta1-4GlcNAcbeta
  参考文献：
  名称：

  Thermodynamic Analysis of Interactions between N-Linked Sugar Chains and F-Box Protein Fbs1

  摘要：

  Fbs1 is a recently discovered F-box protein that was proposed to recognize high-mannose-type asparagine-linked glycoprotein sugar chains. To reveal the specificity of Fbs1, Man alpha 1 -> 6Man beta 1 -> 4GlcNAc(2), Man alpha 1 -> 3Mar beta -> 4GlcNAc(2), and Man alpha 1 -> 3(Man alpha 1 -> 6)Man beta 1 -> 4GlcNAc(2) were synthesized and their affinities for Fbs1 were evaluated in comparison with previously synthesized Man(9)GlcNAc(2) and Man(8)GlcNAc(2). These analyses revealed that Man(3)GlcNAc(2) had the strongest affinity and the chitobiose and alpha 1 -> 6 linked Man residue are necessary for Fbs1 to recognize a sugar.

  DOI：

  10.1021/jm0489511