7-乙氧基喹啉 | 92287-49-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 7-乙氧基喹啉
• 英文名称: 7-ethoxyquinoline
• CAS: 92287-49-5
• 化学式: C₁₁H₁₁NO
• 分子量: 173.214
• InChiKey: OVOZXSUIZQXHCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-乙氧基喹啉 在 N-溴代丁二酰亚胺(NBS) 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  通过不对称转移氢化对轴向手性 5-或 8-取代喹啉进行动力学拆分

  摘要：

  通过杂芳族部分的不对称转移氢化，开发了轴向手性5-或8-取代喹啉衍生物的有效动力学拆分，同时获得了两种具有高达209选择性因子的轴向手性骨架。这代表了杂芳烃的不对称转移氢化在轴向手性联芳烃的动力学拆分中的首次成功应用。

  DOI：

  10.1021/jacs.6b06009
• 作为产物：
  描述：

  7-羟基喹啉 、 碘乙烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以99%的产率得到7-乙氧基喹啉
  参考文献：
  名称：

  Synthesis of 7-Alkoxyquinolines, Coumarins, and Resorufins

  摘要：

  Synthesis of the title compounds by treatment of the sodium salts of 7-quinolinol, 7-hydroxycoumarin, and resorufin with alkyl halides is described.

  DOI：

  10.1080/00397910008087329

文献信息

• Inhibitors of Hepatitis C Virus
  申请人：D'Andrea Stanley

  公开号：US20080107625A1

  公开（公告）日：2008-05-08

  Macrocyclic peptides are disclosed having the general formula: wherein R 3 , R 3 ′, R 4 , R 6 , R′, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

  揭示了具有一般公式的大环肽： 其中描述了R3、R3'、R4、R6、R'、X、Q和W。还公开了包含这些化合物的组合物以及使用这些化合物抑制HCV的方法。
• Hepatitis C virus inhibitors
  申请人：D'Andrea Stanley

  公开号：US20070099825A1

  公开（公告）日：2007-05-03

  Macrocyclic peptides are disclosed having the general formula: wherein R′, R 3 , R 3′ , R 4 , R 6 , X, Q, and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

  大环肽被公开，具有一般的公式： 其中R'，R3，R3'，R4，R6，X，Q和W被描述。还公开了包含该化合物的组合物以及使用该化合物抑制HCV的方法。
• 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS
  申请人：Cook Donald

  公开号：US20090054411A1

  公开（公告）日：2009-02-26

  The invention relates to chemical compounds of formula IA or IB: or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

  该发明涉及化学式IA或IB的化合物：或其药学上可接受的盐，其具有CSF-1R激酶抑制活性，因此在抗癌活性和人或动物体的治疗方法中有用。该发明还涉及制造所述化学化合物的过程，包含它们的制药组合物以及它们在制造用于在温血动物（如人类）中产生抗癌效果的药物中的使用。
• Silver halide photographic emulsions including dye sensitizers and supersensitizing or stabilizing amounts of a polymeric compound, and photographic elements, particularly radiographic elements, including said emulsions
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0027259A1

  公开（公告）日：1981-04-22

  Object of the invention are photographic emulsions including silver halide grains dispersed in gelatin and at least a methine dye spectral sensitizer associated with said grains, including in association therewith a supersensitizing orstabil- izing amount of polymeric compound having an aminoallylidenmalononitrile moiety. The invention further relates to photographic elements, in particular radiographic elements, comprising said emulsions. According to the invention, said polymeric compound is obtained upon copolymerization of an allyl monomer, comprising said aminoallylidenmalononitrile moiety, with an ethylenically unsaturated monomer.

  本发明的目的是照相乳剂，包括分散在明胶中的卤化银颗粒和至少一种与所述颗粒相关联的亚甲基染料光谱感光剂，包括与之相关联的具有氨基烯丙基丙二腈分子的超感光或稳定量的聚合化合物。本发明还涉及包含所述乳剂的照相元件，特别是射线照相元件。根据本发明，烯丙基单体与乙烯基不饱和单体共聚后可得到上述聚合物。
• 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
  申请人：Janssen Pharmaceutica NV

  公开号：US10653711B2

  公开（公告）日：2020-05-19

  Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound: Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (PRMT5).

  本发明的实施方案涉及 6-6 双环芳香环取代的核苷类似物，例如包括以下化合物： 本发明的实施方案还涉及所公开化合物在抑制蛋白精氨酸甲基转移酶5（PRMT5）方面的用途。