1-(3-(6-phenylindolizin-8-yl)phenyl)ethanone | 1418760-44-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3-(6-phenylindolizin-8-yl)phenyl)ethanone
• 英文别名: 1-[3-(6-Phenylindolizin-8-yl)phenyl]ethanone；1-[3-(6-phenylindolizin-8-yl)phenyl]ethanone
• CAS: 1418760-44-7
• 化学式: C₂₂H₁₇NO
• 分子量: 311.383
• InChiKey: AOSYYVGAEADYKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  21.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-乙酰基吡咯 在 potassium phosphate 、 四(三苯基膦)钯 、 sodium hydride 、 potassium carbonate 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 28.0h， 生成 1-(3-(6-phenylindolizin-8-yl)phenyl)ethanone
  参考文献：
  名称：

  Cycloaromatization Approach to Polysubstituted Indolizines from 2-Acetylpyrroles: Decoration of the Pyridine Unit

  摘要：

  A new synthetic route to indolizines with various substituents on the pyridine moiety was developed by utilizing a facile cycloaromatization of 2-acetylpyrrole derivatives. Without isolation, the resulting intermediates were allowed to react with various electrophiles to afford a range of indolizines. In particular, Suzuki-Miyaura cross-coupling of O-triflates with (hetero)arylboronic acids permitted introduction of diverse substituents at the C8 position of an indolizine skeleton.

  DOI：

  10.1021/jo302590a

文献信息

• Cycloaromatization Approach to Polysubstituted Indolizines from 2-Acetylpyrroles: Decoration of the Pyridine Unit
  作者：Jin Ho Lee、Ikyon Kim

  DOI：10.1021/jo302590a

  日期：2013.2.1

  A new synthetic route to indolizines with various substituents on the pyridine moiety was developed by utilizing a facile cycloaromatization of 2-acetylpyrrole derivatives. Without isolation, the resulting intermediates were allowed to react with various electrophiles to afford a range of indolizines. In particular, Suzuki-Miyaura cross-coupling of O-triflates with (hetero)arylboronic acids permitted introduction of diverse substituents at the C8 position of an indolizine skeleton.