10-(3-Fluorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-(3-Fluorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione
• 化学式: C₁₇H₉FN₄O₄
• 分子量: 352.281
• InChiKey: DOGZDQQADMWXLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-(3-fluorophenylamino)-1H-pyrimidine-2,4-dione 、 2-氯-5-硝基苯甲醛 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 以63%的产率得到10-(3-Fluorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione
  参考文献：
  名称：

  Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells

  摘要：

  A family of 5-deazaflavin derivatives has been synthesised using a two-step convergent strategy. The biological activity of these compounds was evaluated in cells, by assessing their ability to stabilize and activate p53. These compounds may act as low molecular weight inhibitors of the E3 activity of HMD2 in tumours that retain wild-type p53. Importantly, we have demonstrated that the nitro group present in all three of the original lead compounds [1-3 (HL198C-E)] is not essential for observation of this biological activity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.10.011