7-氯-6-[4-(二乙基氨基)苯基]-5,8-喹啉二酮 | 389614-94-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 7-氯-6-[4-(二乙基氨基)苯基]-5,8-喹啉二酮
• 英文名称: 7-Chloro-6-[4-(diethylamino)phenyl]quinoline-5,8-dione
• CAS: 389614-94-2
• 化学式: C₁₉H₁₇ClN₂O₂
• 分子量: 340.8
• InChiKey: XAZVKSMDPVMMPP-UHFFFAOYSA-N

物化性质

• 沸点：
  508.3±50.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)
• 溶解度：
  DMSO 中≤1mg/ml；二甲基甲酰胺中≤20mg/ml

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  50.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Phospholipase A2 enzyme, antibodies and inhibitors thereto
  申请人：——

  公开号：US20040001834A1

  公开（公告）日：2004-01-01

  The disclosed invention relates to a novel rPLA 2 enzyme, it's antibody and use and the preparation method. The purified enzyme, derived from RBC cytosol, produces arachidonic acid dependently to calcium ion, has 42 kDa of M.W. determined by SDS-PAGE analysis, shows its isoeletric point at the pH ranging 3.9 to about 4.1 in electrophoresis analysis, has maximum activity at the pH ranging 9.5 to 10 and has its specific activity of 5.6 nM/min/mg. The antibody of disclosed invention reacts with the enzyme rPLA 2 only and rPLA 2 is inactivated by EA4 compound, rPLA 2 inhibitor. The disclosed invention shows that the 42 kDa rPLA 2 identified as a novel form of Ca 2+ -dependent PLA 2 plays an important role in hemostasis, thrombosis and/or erythropoiesis through the Ca 2+ -dependent release of AA.
• [EN] NOVEL PLA>2< ENZYME, IT'S ANTIBODY, ENZYME INHIBITOR AND USE AND THE PREPARATION METHODS THEREOF<br/>[FR] NOUVELLE ENZYME PLA2, SON ANTICORPS, INHIBITEUR DE CETTE ENZYME ET UTILISATION ET PROCEDES DE PREPARATION DE CELLE-CI
  申请人：KIM DAE-KYONG

  公开号：WO2004003193A1

  公开（公告）日：2004-01-08

  The present invention relates to a novel rPLA2 enzyme, it's antibody and use and the preparation method. The purified enzyme, derived from RBC cytosol, produces arachidonic acid dependently to calcium ion, has 42kDa of M.W. determined by SDS-PAGE analysis, shows its isoeletric point at the pH ranging 3.9 to 4.1 in electrophoresis analysis, has maximum activity at the pH ranging 9.5 to 10 and has its specific activity of 5.6 nM/min/mg. The antibody of present invention reacts with the enzyme rPLA2 only and inventive rPLA2 is inactivated by EA4 compund, rPLA2 inhibitor.The present invention shows that the 42 kDa rPLA2 identified as a novel form of Ca2+-dependent PLA¿2? may play an important role in hemostasis, thrombosis and/or erythropoiesis through the Ca?2+¿-dependent release of AA.