tert-butyl 4-{3-[4-(2-isopropyl-phenylsulfanyl)-3-nitrophenyl]acryloyl}piperazine-1-carboxylate | 280749-84-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: tert-butyl 4-{3-[4-(2-isopropyl-phenylsulfanyl)-3-nitrophenyl]acryloyl}piperazine-1-carboxylate
• 英文别名: (2-Isopropylphenyl)[2-nitro-4-(E-((4-tert-butoxycarbonylpiperazin-1-yl)carbonyl)ethenyl)phenyl]sulfide；tert-butyl 4-[(E)-3-[3-nitro-4-(2-propan-2-ylphenyl)sulfanylphenyl]prop-2-enoyl]piperazine-1-carboxylate
• CAS: 280749-84-0
• 化学式: C₂₇H₃₃N₃O₅S
• 分子量: 511.642
• InChiKey: PEZIGBVULRQTAW-ACCUITESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  121
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butyl 4-{3-[4-(2-isopropyl-phenylsulfanyl)-3-nitrophenyl]acryloyl}piperazine-1-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以95%的产率得到(E)-3-[4-(2-Isopropyl-phenylsulfanyl)-3-nitro-phenyl]-1-piperazin-1-yl-propenone
  参考文献：
  名称：

  Discovery of Potent Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 3. Amide (C-Ring) Structure−Activity Relationship and Improvement of Overall Properties of Arylthio Cinnamides

  摘要：

  The interaction of LFA-1 and ICAM-1 plays an important role in the cell adhesion process. On the basis of previously reported SAR and structural information on the binding of our p-arylthiocinnamide series to LFA-1, we have identified the cyclic amide (C-ring) as a site for modification. Improvement in potency and, more importantly, in the physical properties and pharmacokinetic profiles of the leading compounds resulted from this modification. One of the best compounds (11f) is also shown to reduce myocardial infarct size in rat.

  DOI：

  10.1021/jm010059w
• 作为产物：
  描述：

  N-Boc-哌嗪 、 3-[4-(2-isopropylphenylsulfanyl)-3-nitrophenyl]acrylic acid 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以80%的产率得到tert-butyl 4-{3-[4-(2-isopropyl-phenylsulfanyl)-3-nitrophenyl]acryloyl}piperazine-1-carboxylate
  参考文献：
  名称：

  Discovery of Potent Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 3. Amide (C-Ring) Structure−Activity Relationship and Improvement of Overall Properties of Arylthio Cinnamides

  摘要：

  The interaction of LFA-1 and ICAM-1 plays an important role in the cell adhesion process. On the basis of previously reported SAR and structural information on the binding of our p-arylthiocinnamide series to LFA-1, we have identified the cyclic amide (C-ring) as a site for modification. Improvement in potency and, more importantly, in the physical properties and pharmacokinetic profiles of the leading compounds resulted from this modification. One of the best compounds (11f) is also shown to reduce myocardial infarct size in rat.

  DOI：

  10.1021/jm010059w

文献信息

• CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS
  申请人：ABBOTT LABORATORIES

  公开号：EP1140814A2

  公开（公告）日：2001-10-10
• [EN] CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS<br/>[FR] COMPOSES ANTI-INFLAMMATOIRES ET IMMUNOSUPPRESSEURS INHIBANT L'ADHESION CELLULAIRE
  申请人：ABBOTT LAB

  公开号：WO2000039081A2

  公开（公告）日：2000-07-06

  The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
• Discovery of Potent Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 3. Amide (C-Ring) Structure−Activity Relationship and Improvement of Overall Properties of Arylthio Cinnamides
  作者：Zhonghua Pei、Zhili Xin、Gang Liu、Yihong Li、Edward B. Reilly、Nathan L. Lubbers、Jeffery R. Huth、James T. Link、Thomas W. von Geldern、Bryan F. Cox、Sandra Leitza、Yi Gao、Kennan C. Marsh、Peter DeVries、Greg F. Okasinski

  DOI：10.1021/jm010059w

  日期：2001.8.1

  The interaction of LFA-1 and ICAM-1 plays an important role in the cell adhesion process. On the basis of previously reported SAR and structural information on the binding of our p-arylthiocinnamide series to LFA-1, we have identified the cyclic amide (C-ring) as a site for modification. Improvement in potency and, more importantly, in the physical properties and pharmacokinetic profiles of the leading compounds resulted from this modification. One of the best compounds (11f) is also shown to reduce myocardial infarct size in rat.