methyl 1H-pyrazolo[3,4-b]pyridine-4-carboxylate | 1638769-07-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: methyl 1H-pyrazolo[3,4-b]pyridine-4-carboxylate
• 英文别名: Methyl 1H-pyrazolo[3,4-b]pyridine-4-carboxylate
• CAS: 1638769-07-9
• 化学式: C₈H₇N₃O₂
• 分子量: 177.162
• InChiKey: VNALUAYRSSZMJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 1H-pyrazolo[3,4-b]pyridine-4-carboxylate 在 potassium hydroxide 、 碘 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以87 %的产率得到methyl 3-iodo-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
  参考文献：
  名称：

  [EN] THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER
  [FR] COMPOSÉS D'INDAZOLE THÉRAPEUTIQUES ET MÉTHODES D'UTILISATION DANS LE TRAITEMENT DU CANCER

  摘要：

  This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

  公开号：

  WO2023097195A1
• 作为产物：
  描述：

  4-氯-7-氮杂吲唑,4-氯吡唑并[3,4-B]吡啶 在 氢溴酸 、 palladium diacetate 、 sodium carbonate 、 溶剂黄146 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 methyl 1H-pyrazolo[3,4-b]pyridine-4-carboxylate
  参考文献：
  名称：

  [EN] THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER
  [FR] COMPOSÉS D'INDAZOLE THÉRAPEUTIQUES ET MÉTHODES D'UTILISATION DANS LE TRAITEMENT DU CANCER

  摘要：

  This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

  公开号：

  WO2023097195A1

文献信息

• [EN] SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE 6-(4-HYDROXYPHÉNYL)-1H-PYRAZOLO[3,4-B]PYRIDINE SUBSTITUÉS UTILISÉS COMME INHIBITEURS DE KINASES
  申请人：SANOFI SA

  公开号：WO2013167403A1

  公开（公告）日：2013-11-14

  Substituted 6-(4-Hydroxy-phenyl)-l H-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula, in which R', R2 , R3, R4, R5 and R6 are defined as indicated below. The compounds of the formula I are proteine kinase C (PKC) inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

  本发明涉及一种式为pyrazolo[3,4-b]pyridine的化合物，其中R'、R2、R3、R4、R5和R6如下所示。公式I的化合物是蛋白激酶C（PKC）抑制剂，可用于治疗与糖尿病和糖尿病并发症相关的疾病，例如糖尿病肾病、糖尿病神经病和糖尿病视网膜病变。此外，本发明还涉及将该化合物用作药物的活性成分，以及包含它们的制药组合物。
• SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS
  申请人：SANOFI

  公开号：EP2847191A1

  公开（公告）日：2015-03-18
• [EN] THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER<br/>[FR] COMPOSÉS D'INDAZOLE THÉRAPEUTIQUES ET MÉTHODES D'UTILISATION DANS LE TRAITEMENT DU CANCER
  申请人：[en]GENENTECH, INC.

  公开号：WO2023097195A1

  公开（公告）日：2023-06-01

  This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.