1-Cyclopropyl-3-methoxy-propylamine | 512847-50-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Cyclopropyl-3-methoxy-propylamine
• 英文别名: 1-Cyclopropyl-3-methoxypropan-1-amine
• CAS: 512847-50-6
• 化学式: C₇H₁₅NO
• 分子量: 129.202
• InChiKey: RWNOVNJPDXMCGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Cyclopropyl-3-methoxy-propylamine 在 ammonium hydroxide 、 sodium dithionite 作用下， 以 1,4-二氧六环 、 水 、 乙腈 为溶剂， 生成 N²-(1-Cyclopropyl-3-methoxy-propyl)-4-(2,4-dichloro-phenyl)-pyridine-2,3-diamine
  参考文献：
  名称：

  Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands

  摘要：

  A series of high affinity CRF receptor ligands with an imidazo[4,5-b]pyridine core is described. Individual analogues were synthesized and tested in a rat CRF receptor binding assay. The best compounds were further tested in the dog N-in-1 pharmaco-kinetic model to assess plasma levels at 1 mg/kg (po) and in the rat situational anxiety model to assess anxiolytic efficacy at 3 mg/kg (po). The structure-activity relationships for good receptor binding affinity are described herein. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00833-8
• 作为产物：
  描述：

  cyclopropyl methyl ketone oxime methyl ether 在 lithium aluminium tetrahydride 、 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 生成 1-Cyclopropyl-3-methoxy-propylamine
  参考文献：
  名称：

  Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands

  摘要：

  A series of high affinity CRF receptor ligands with an imidazo[4,5-b]pyridine core is described. Individual analogues were synthesized and tested in a rat CRF receptor binding assay. The best compounds were further tested in the dog N-in-1 pharmaco-kinetic model to assess plasma levels at 1 mg/kg (po) and in the rat situational anxiety model to assess anxiolytic efficacy at 3 mg/kg (po). The structure-activity relationships for good receptor binding affinity are described herein. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00833-8

文献信息

• Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands
  作者：Argyrios G. Arvanitis、Joseph T. Rescinito、Charles R. Arnold、Richard G. Wilde、Gary A. Cain、Jung Hui Sun、Jia-Sheng Yan、Christopher A. Teleha、Lawrence W. Fitzgerald、John McElroy、Robert Zaczek、Paul R. Hartig、Scott Grossman、Stephen P. Arneric、Paul J. Gilligan、Richard E. Olson、David W. Robertson

  DOI：10.1016/s0960-894x(02)00833-8

  日期：2003.1

  A series of high affinity CRF receptor ligands with an imidazo[4,5-b]pyridine core is described. Individual analogues were synthesized and tested in a rat CRF receptor binding assay. The best compounds were further tested in the dog N-in-1 pharmaco-kinetic model to assess plasma levels at 1 mg/kg (po) and in the rat situational anxiety model to assess anxiolytic efficacy at 3 mg/kg (po). The structure-activity relationships for good receptor binding affinity are described herein. (C) 2002 Elsevier Science Ltd. All rights reserved.