6-chloro-2,4,6-trideoxyhexose | 488085-04-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-chloro-2,4,6-trideoxyhexose
• 英文别名: 6-Chloro-3,5-dihydroxyhexanal
• CAS: 488085-04-7
• 化学式: C₆H₁₁ClO₃
• mdl: MFCD19236607
• 分子量: 166.605
• InChiKey: ZRPLUEXPLPUZFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  氯乙醛 、 乙醛 在 thermotoga maritima-derived DERA 作用下， 反应 24.0h， 生成 4-chloro-3-hydroxybutylaldehyde 、 6-chloro-2,4,6-trideoxyhexose
  参考文献：
  名称：

  Process for producing chiral hydroxyaldehyde compounds

  摘要：

  一种工业生产羟基醛的方法，有效解决了传统的DERA存在的问题，如对醛类的稳定性低、醛缩反应的催化活性低以及难以控制要缩合的乙醛分子数等问题。根据该方法，使用高度稳定且对醛缩反应具有高催化活性的D-2-脱氧核糖-5-磷酸醛缩酶，对具有2到6个碳原子的取代或未取代的脂肪族醛化合物与乙醛进行醛缩反应，从而可以生产出碳原子数增加两个或四个的羟基醛化合物。

  公开号：

  US07402710B2

文献信息

• PROCESS FOR PRODUCTION OF CHIRAL HYDROXYALDEHYDES
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1734129A1

  公开（公告）日：2006-12-20

  An industrial process for producing hydroxyaldehydes efficiently, by solving the problems of conventional DERA, such as low stability against aldehydes, low catalytic activity for aldol condensation, and the difficulty of controlling the number of acetaldehyde molecules to be condensed, is provided. According to the process, aldol condensation of a substituted or unsubstituted aliphatic aldehyde compound having 2 to 6 carbon atoms with acetaldehyde is conducted by using D-2-deoxyribose-5-phosphate aldolase which is highly stable against aldehydes and has high catalytic activity for aldol condensation, whereby a hydroxyaldehyde compound having the number of carbon atoms increased by two or four can be produced.

  本发明提供了一种高效生产羟基醛的工业工艺，解决了传统 DERA 存在的问题，如对醛稳定性低、醛缩合催化活性低以及难以控制缩合的乙醛分子数。 根据该工艺，通过使用对醛高度稳定、对醛缩合具有高催化活性的 D-2 脱氧核糖-5-磷酸醛缩酶，将具有 2 至 6 个碳原子的取代或未取代脂肪醛化合物与乙醛进行醛缩合，从而生产出碳原子数增加 2 或 4 个的羟醛化合物。
• Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses
  申请人：——

  公开号：US20040171125A1

  公开（公告）日：2004-09-02

  The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one &agr;-hydrogen atom and a substituted or unsubstituted aldehyde in the presence of an aldolase and water, the reaction between the substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one &agr;-hydrogen atom and the substituted or unsubstituted aldehyde being carried out at a carbonyl concentration of at most 6 moles/l of reaction mixture and the final concentration of the 2,4-dideoxyhexose or the 2,4,6-trideoxyhexose being at least 2 mass % of the reaction mixture. The invention also relates to the use of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose obtained by means of a process according to the invention in the preparation of a medicine, particularly in the preparation of a statine.

  本发明涉及一种在醛缩酶和水的存在下，由具有至少 2 个碳原子和至少 1 个&agr;-氢原子的取代或未取代羰基化合物和取代或未取代醛制备 2,4-二脱氧己糖或 2,4,6-三脱氧己糖的工艺，具有至少 2 个碳原子和至少 1 个&agr;-氢原子的取代或未取代羰基化合物和取代或未取代醛之间的反应在羰基浓度最多为 6 摩尔/升的反应混合物中进行，最终浓度为 2,4-二脱氧己糖或 2,4,6-三脱氧己糖；-氢原子的取代或未取代的羰基化合物与取代或未取代的醛之间的反应是在羰基浓度为至多 6 摩尔/升的反应混合物中进行的，2,4-二脱氧己糖或 2,4,6-三脱氧己糖的最终浓度至少为反应混合物的 2 质量％。本发明还涉及将通过本发明工艺获得的 2,4-二脱氧己糖或 2,4,6-三脱氧己糖用于制备药物，特别是制备他汀类药物。
• PROCESS FOR THE PREPARATION OF 2,4-DIDEOXYHEXOSES AND 2,4,6-TRIDEOXYHEXOSES
  申请人：DSM IP Assets B.V.

  公开号：EP1404844B1

  公开（公告）日：2007-03-07
• Process For Producing Chiral Hydroxyaldehyde Compounds
  申请人：Matsumoto Kazuya

  公开号：US20070196906A1

  公开（公告）日：2007-08-23

  An industrial process for producing hydroxyaldehydes efficiently, by solving the problems of conventional DERA, such as low stability against aldehydes, low catalytic activity for aldol condensation, and the difficulty of controlling the number of acetaldehyde molecules to be condensed, is provided. According to the process, aldol condensation of a substituted or unsubstituted aliphatic aldehyde compound having 2 to 6 carbon atoms with acetaldehyde is conducted by using D-2-deoxyribose-5-phosphate aldolase which is highly stable against aldehydes and has high catalytic activity for aldol condensation, whereby a hydroxyaldehyde compound having the number of carbon atoms increased by two or four can be produced.
• US6964863B2
  申请人：——

  公开号：US6964863B2

  公开（公告）日：2005-11-15