(2-methoxy-9-oxo-7-propanoyl-11H-indolizino[1,2-b]quinolin-8-yl)methyl formate | 1260237-43-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (2-methoxy-9-oxo-7-propanoyl-11H-indolizino[1,2-b]quinolin-8-yl)methyl formate
• CAS: 1260237-43-1
• 化学式: C₂₁H₁₈N₂O₅
• 分子量: 378.384
• InChiKey: VYNTVTHQSPVUBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  85.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2-methoxy-9-oxo-7-propanoyl-11H-indolizino[1,2-b]quinolin-8-yl)methyl formate 在 sodium tetrahydroborate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of new cytotoxic E-ring modified camptothecins

  摘要：

  In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.130
• 作为产物：
  描述：

  (4S)-4-ethyl-3,4-dihydroxy-9-methoxy-3,4-dihydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-14(12H)-one 在 silica-gel supported NaIO₄ 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以60%的产率得到(2-methoxy-9-oxo-7-propanoyl-11H-indolizino[1,2-b]quinolin-8-yl)methyl formate
  参考文献：
  名称：

  Synthesis of new cytotoxic E-ring modified camptothecins

  摘要：

  In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.130

文献信息

• Synthesis of new cytotoxic E-ring modified camptothecins
  作者：Salvatore Cananzi、Sabrina Dallavalle、Alberto Bargiotti、Lucio Merlini、Roberto Artali、Giovanni Luca Beretta

  DOI：10.1016/j.tetlet.2010.09.130

  日期：2010.12

  In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460. (C) 2010 Elsevier Ltd. All rights reserved.