3-(2-chlorophenyl)-5-methyl-N-quinolin-8-yl-1,2-oxazole-4-carboxamide | 5857-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(2-chlorophenyl)-5-methyl-N-quinolin-8-yl-1,2-oxazole-4-carboxamide
• CAS: 5857-85-2
• 化学式: C₂₀H₁₄ClN₃O₂
• mdl: MFCD00116172
• 分子量: 363.8
• InChiKey: JMQGEQWKAAJVEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• AGENTS AND METHODS FOR TREATING ISCHEMIC AND OTHER DISEASES
  申请人：Sun Xiujun

  公开号：US20110251182A1

  公开（公告）日：2011-10-13

  This invention relates to methods of screening for modulators of mammalian cell injury cause by TRPM7 gene and protein activity, compounds that modulate TRPM7 gene and protein activity and methods of treatment of mammalian cell injury using modulators of TRPM7 gene and protein activity.
• US9566284B2
  申请人：——

  公开号：US9566284B2

  公开（公告）日：2017-02-14
• [EN] AMIDES OF 3, 5-SUBSTITUTED-IS0XAZ0LE-4-CARB0XYLIC ACIDS FOR THE TREATMENT OF VIRAL INFECTIONS, CANCER AND RESTENOSIS<br/>[FR] AMIDES D'ACIDES ISOXAZOLE-4-CARBOXYLIQUES SUBSTITUÉS EN POSITION 3 ET 5 POUR LE TRAITEMENT D'INFECTIONS VIRALES, D'UN CANCER ET D'UNE RESTÉNOSE
  申请人：CLEVELAND CLINIC FOUNDATION

  公开号：WO2009123588A1

  公开（公告）日：2009-10-08

  The invention is directed to the use of compounds of Formula I as anti-viral agents, anti-cancer agents and agents for inhibiting restenosis: NR2R3 The variables in Formula (I) are defined herein.