(3,4-dimethylcyclohex-3-en-1-yl)methanol | 39155-41-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3,4-dimethylcyclohex-3-en-1-yl)methanol
• CAS: 39155-41-4
• 化学式: C₉H₁₆O
• 分子量: 140.225
• InChiKey: STYNQPWPNFPCLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (3,4-dimethylcyclohex-3-en-1-yl)methanol 在 咪唑 、 正丁基锂 、 四丁基氟化铵 、 碘 、 三苯基膦 作用下， 以 四氢呋喃 、 hexanes 、 苯 为溶剂， 反应 19.58h， 生成 4-((3,4-dimethylcyclohex-3-en-1-yl)methyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide
  参考文献：
  名称：

  [EN] 4-SUBSTITUTED IMIDAZOLE-2-THIONES AND IMIDAZOL-2-ONES AS AGONISTS OF THE ALPHA-2B AND ALPHA-2C ADRENERGIC RECEPTORS
  [FR] IMIDAZOLE-2-ONES ET IMIDAZOLE-2-THIONES 4 SUBSTITUES COMME AGONISTES DES ADRENO-RECEPTEURS ALPHA-2B ET ALPHA-2C

  摘要：

  式(I)的化合物：其中X为S，变量的含义如规范中定义的那样，对alpha2B和/或alpha2C肾上腺素受体具有特异性或选择性，优先于alpha2A肾上腺素受体，并且因此具有无或仅有极小的心血管和/或镇静活性。这些式(I)的化合物在哺乳动物，包括人类中，作为药物用于治疗对alpha2B肾上腺素受体激动剂治疗有响应的疾病和/或缓解症状是有用的。式(I)的化合物，其中X为O，还具有有利的特性，即它们具有无或仅有极小的心血管和/或镇静活性，并且适用于治疗无或仅有极小的心血管和/或镇静活性的疼痛和其他症状。

  公开号：

  WO2003099795A1
• 作为产物：
  描述：

  3,4-二甲基-3-环己烯甲醛 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 (3,4-dimethylcyclohex-3-en-1-yl)methanol
  参考文献：
  名称：

  Guiotto; Rodighiero; Fornasiero, Farmaco, Edizione Scientifica, 1972, vol. 27, # 12, p. 1045 - 1052

  摘要：

  DOI：

文献信息

• Synthesis of 1,3-Cycloalkadienes from Cycloalkenes: Unprecedented Reactivity of Oxoammonium Salts
  作者：Shota Nagasawa、Yusuke Sasano、Yoshiharu Iwabuchi

  DOI：10.1002/anie.201607752

  日期：2016.10.10

  Few methods allow for the direct conversion of cycloalkenes into cycloalkadienes with high chemo‐ and regioselectivity. Herein, we report a convenient one‐pot process for this transformation that involves the unprecedented N‐preferential group transfer of N‐oxoammonium salts to cycloalkenes, followed by Cope elimination, to afford cycloalkadienes at room temperature and pressure.

  很少有方法能够将环烯烃直接转化为具有高化学和区域选择性的环烷二烯。在此，我们提出一个方便的一锅法用于该转化，其涉及的前所未有的N-优先基团转移Ñ -oxoammonium盐环烯烃，随后柯普消除，以得到在室温和压力环二烯。
• [EN] PERFUME SYSTEMS<br/>[FR] SYSTÈMES DE PARFUM
  申请人：PROCTER & GAMBLE

  公开号：WO2015148743A1

  公开（公告）日：2015-10-01

  The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

  本申请涉及香水原料、香水传递系统和包含这些香水原料和/或香水传递系统的消费品，以及制造和使用这些香水原料、香水传递系统和消费品的过程。本文披露的香水原料和组合物，包括传递系统，扩展了香水社区的选择，因为这些香水原料可以提供不同的特性变化，这些组合物可以提供所需的气味特征。
• 4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOLE-2-THIONES, 4-(SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOLE-2-THIONES, 4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOL-2-ONES AND 4-(SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOL-2-ONES AND RELATED COMPOUNDS
  申请人：Chow Ken

  公开号：US20070072926A1

  公开（公告）日：2007-03-29

  Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha 2B and/or alpha 2C adrenergic receptors in preference over alpha 2A adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha 2B adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.

  式1中X为S且变量的含义已在说明书中定义，这些化合物具有特异性或选择性作用于α2B和/或α2C肾上腺素受体，而不是α2A肾上腺素受体，因此它们没有或仅有最小的心血管和/或镇静活性。这些式1的化合物可用作哺乳动物，包括人类的药物，用于治疗对α2B肾上腺素受体激动剂有反应的疾病和/或缓解条件。式1中X为O的化合物还具有优越的特性，即它们没有或仅有最小的心血管和/或镇静活性，可用于治疗无或仅有最小心血管和/或镇静活性的疼痛和其他病症。
• 4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOLE-2-THIONES, 4-(SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOLE-2-THIONES, 4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOLE-2-ONES AND, 4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOLE-2-ONES AND RELATED COMPOUNDS
  申请人：Chow Ken

  公开号：US20080319013A1

  公开（公告）日：2008-12-25

  Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha 2B and/or alpha 2C adrenergic receptors in preference over alpha 2A adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha 2B adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.

  化学式为1的化合物中，其中X为S，变量的含义在说明书中定义，具有对alpha2B和/或alpha2C肾上腺素受体的特异性或选择性，而不是alpha2A肾上腺素受体，因此具有无或仅有最少的心血管和/或镇静活性。这些化合物可用作哺乳动物，包括人类，治疗对alpha2B肾上腺素受体激动剂有反应的疾病和/或缓解病情。化学式为1的化合物中，其中X为O也具有优越的特性，即它们没有或仅有最少的心血管和/或镇静活性，可用于治疗无或仅有最少心血管和/或镇静活性的疼痛和其他疾病。
• 4-(2-METHYL-5,6,7,8-TETRAHYDRO-QUINOLIN-7-YLMETHYL)-1,3-DIHYDRO-IMIDAZOLE-2-THIONE AS SPECIFIC ALPHA2B AGONIST AND METHODS OF USING THE SAME
  申请人：Heidelbaugh M. Todd

  公开号：US20080070945A1

  公开（公告）日：2008-03-20

  The compound of the formula wherein the * indicates an asymmetric carbon, is specific to alpha 2B adrenergic receptors in preference over alpha 2A and alpha 2C adrenergic receptors, and as such has no or only minimal cardivascular and/or sedatory activity. The compound is useful as medicament in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha 2B adrenergic receptors.

  该化学式中的 * 表示对称碳原子，其化合物对α2B肾上腺素受体具有特异性，优先于α2A和α2C肾上腺素受体，因此具有极小的心血管和/或镇静作用或没有作用。该化合物可用作哺乳动物，包括人类，治疗对α2B肾上腺素受体激动剂敏感的疾病和/或缓解条件的药物。