3-O-(2-oxo-2-phenylethyl)karanjonol | 1244042-51-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-O-(2-oxo-2-phenylethyl)karanjonol
• 英文别名: 3-O-(2-Oxo-2-phenyl-ethyl)-karanjonol；3-phenacyloxy-2-phenylfuro[2,3-h]chromen-4-one
• CAS: 1244042-51-0
• 化学式: C₂₅H₁₆O₅
• 分子量: 396.399
• InChiKey: VOGZECCZNNRXNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  65.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  水黄皮素 在 三溴化硼 、 potassium carbonate 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 8.5h， 生成 3-O-(2-oxo-2-phenylethyl)karanjonol
  参考文献：
  名称：

  Synthesis of analogues of antihyperglycemic lead karanjin

  摘要：

  Karanjin isolated in gram scale from Pongamia pinnata was subjected to transformation reactions and 11 analogues were prepared and evaluated for their antihyperglycemic activity in streptozotocin-induced diabetic rats, and compared with the standard drug metformin at the dose of 100 mg/kg body weight. Four derivatives showed comparable activity with metformin.

  DOI：

  10.1007/s00044-010-9387-1

文献信息

• Synthesis of analogues of antihyperglycemic lead karanjin
  作者：Akanksha、Prem P. Yadav、Arvind K. Srivastava、Rakesh Maurya

  DOI：10.1007/s00044-010-9387-1

  日期：2011.12

  Karanjin isolated in gram scale from Pongamia pinnata was subjected to transformation reactions and 11 analogues were prepared and evaluated for their antihyperglycemic activity in streptozotocin-induced diabetic rats, and compared with the standard drug metformin at the dose of 100 mg/kg body weight. Four derivatives showed comparable activity with metformin.