(2-aminopyridin-3-yl)(4-methoxyphenyl)methanone | 945589-60-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-aminopyridin-3-yl)(4-methoxyphenyl)methanone
• 英文别名: (2-Aminopyridin-3-yl)-(4-methoxyphenyl)methanone
• CAS: 945589-60-6
• 化学式: C₁₃H₁₂N₂O₂
• 分子量: 228.25
• InChiKey: JCQQUGDCYMSEMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  65.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-aminopyridin-3-yl)(4-methoxyphenyl)methanone 在 吡啶 、 sodium hydroxide 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-methyl-4-(4-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic acid
  参考文献：
  名称：

  Synthesis and structure–activity relationship studies on a novel series of naphthylidinoylureas as inhibitors of acyl-CoA:cholesterol O -acyltransferase (ACAT)

  摘要：

  The synthesis and structure-activity relationships of N-phenyl-N'-[3-(4-phenylnaphthylidinoyl)]urea derivatives 3 as a novel structural class of potent ACAT inhibitors is described. A 3-methoxy group substituted on the naphthylidinone 4-phenyl ring, together with a 1-N-(n)butyl substitution, SM-32504 (3m), gave a potent ACAT inhibitor, in vitro, respectively. The most potent compound, SM-32504 (3m), decreased the serum cholesterol level significantly in a high fat and high cholesterol-fed mouse model. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.045
• 作为产物：
  描述：

  2-特戊酰胺基吡啶 在 盐酸 、 manganese(IV) oxide 、 正丁基锂 、 四甲基乙二胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (2-aminopyridin-3-yl)(4-methoxyphenyl)methanone
  参考文献：
  名称：

  Synthesis and structure–activity relationship studies on a novel series of naphthylidinoylureas as inhibitors of acyl-CoA:cholesterol O -acyltransferase (ACAT)

  摘要：

  The synthesis and structure-activity relationships of N-phenyl-N'-[3-(4-phenylnaphthylidinoyl)]urea derivatives 3 as a novel structural class of potent ACAT inhibitors is described. A 3-methoxy group substituted on the naphthylidinone 4-phenyl ring, together with a 1-N-(n)butyl substitution, SM-32504 (3m), gave a potent ACAT inhibitor, in vitro, respectively. The most potent compound, SM-32504 (3m), decreased the serum cholesterol level significantly in a high fat and high cholesterol-fed mouse model. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.045

文献信息

• COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME
  申请人：Eto Nobuaki

  公开号：US20120115851A1

  公开（公告）日：2012-05-10

  An objective of the present invention is to provide compounds that can effectively suppress the concentration of phosphorus in serum to effectively prevent or treat diseases induced by an increase in concentration of phosphate in serum. The compounds according to the present invention are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein A represents an optionally substituted five- to nine-membered unsaturated carbocyclic moiety or a five- to nine-membered unsaturated heterocyclic moiety, and represents a single bond or a double bond, R 5 represents optionally substituted aryl or the like, Z represents —N═CHR 6 R 7 or the like, R 6 and R 7 represent H, optionally substituted alkyl, optionally substituted aryl or the like, R 101 and R 102 together form ═O, and R 103 and R 104 represent H, or R 101 and R 104 together from a bond, and R 102 and R 103 together form a bond.

  本发明的目标是提供能够有效抑制血清中磷浓度的化合物，以有效预防或治疗由血清中磷酸盐浓度增加引起的疾病。本发明的化合物是由式（I）表示的化合物及其药学上可接受的盐和溶剂化物：其中，A代表可选取代的五至九元不饱和碳环基或五至九元不饱和杂环基，表示单键或双键，R5代表可选取代的芳基或类似物，Z代表—N═CHR6R7或类似物，R6和R7代表H、可选取代的烷基、可选取代的芳基或类似物，R101和R102共同形成═O，R103和R104代表H，或R101和R104共同形成键，R102和R103共同形成键。
• Synthesis of aza analogues of the anticancer agent batracylin
  作者：Carlos M. Martínez-Viturro、Domingo Domínguez

  DOI：10.1016/j.tetlet.2007.05.025

  日期：2007.7

  Three series of pyrido-fused pyrimido[2,1-a]isoindol-7-ones were prepared from readily available (aminopyridinyl)(aryl)methanones by reduction followed by a Mitsunobu reaction with phthalimide and acid-catalysed cyclodehydration. This approach provides a wide variety of aza analogues of the antitumour agent batracylin. (c) 2007 Elsevier Ltd. All rights reserved.
• Synthesis and structure–activity relationship studies on a novel series of naphthylidinoylureas as inhibitors of acyl-CoA:cholesterol O -acyltransferase (ACAT)
  作者：Satoshi Ohnuma、Masami Muraoka、Katsuhisa Ioriya、Naohito Ohashi

  DOI：10.1016/j.bmcl.2003.12.045

  日期：2004.3

  The synthesis and structure-activity relationships of N-phenyl-N'-[3-(4-phenylnaphthylidinoyl)]urea derivatives 3 as a novel structural class of potent ACAT inhibitors is described. A 3-methoxy group substituted on the naphthylidinone 4-phenyl ring, together with a 1-N-(n)butyl substitution, SM-32504 (3m), gave a potent ACAT inhibitor, in vitro, respectively. The most potent compound, SM-32504 (3m), decreased the serum cholesterol level significantly in a high fat and high cholesterol-fed mouse model. (C) 2004 Elsevier Ltd. All rights reserved.