p-Isopropyl-α-ethylzimtsaeure | 53086-38-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: p-Isopropyl-α-ethylzimtsaeure
• 英文别名: 2-ethyl-3-(4-isopropyl-phenyl)-acrylic acid；α-Cuminal-buttersaeure；α-(4-Isopropyl-phenyl)-α-butylen-β-carbonsaeure；α-Aethyl-4-isopropyl-zimtsaeure；2-Aethyl-3-(4-isopropyl-phenyl)-acrylsaeure；2-[(4-Propan-2-ylphenyl)methylidene]butanoic acid
• CAS: 53086-38-7
• 化学式: C₁₄H₁₈O₂
• 分子量: 218.296
• InChiKey: CBUSMMIODONDHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  p-Isopropyl-α-ethylzimtsaeure 在 氢溴酸 作用下， 生成 2-(α-bromo-4-isopropyl-benzyl)-butyric acid
  参考文献：
  名称：

  Perkin, Journal of the Chemical Society, 1877, vol. 32, p. 667

  摘要：

  DOI：
• 作为产物：
  描述：

  丁酸酐 、 4-异丙基苯甲醛 在 sodium acetate 作用下， 生成 p-Isopropyl-α-ethylzimtsaeure
  参考文献：
  名称：

  Perkin, Journal of the Chemical Society, 1877, vol. 31, p. 409

  摘要：

  DOI：

文献信息

• COSMETIC
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20200281836A1

  公开（公告）日：2020-09-10

  A cosmetic containing (A) an organo(poly)siloxane shown by the following general formula (1). A cosmetic with a refreshing feeling, smooth spreadability as well as high stability and favorable cosmetic sustainability is provided. [where, in the formula, R 1 represents a group except shown by the formula (2), selected from a C1-C20 alkyl group and a C6-C20 aryl group; n represents an integer of 0 to 3; R 2 and R 3 represent R 1 or the formula (2); and either or both of R 2 and R 3 represent formula (2), (where, in the formula, X represents a C2-C20 alkylene group; and Y represents any one of a hydrogen atom, a C1-C20 alkyl group, a C6-C20 aryl group, a C7-C40 aralkyl group, a C1-C20 alkyloxy group, a C6-C20 aryloxy group, a C7-C40 arylalkyloxy group, and a halogen atom.)]

  一种化妆品，含有以下一般式（1）所示的有机（聚）硅氧烷。提供一种具有清爽感、平滑涂抹性以及高稳定性和良好的化妆品持久性的化妆品。【在公式中，R1代表除公式（2）所示之外的一种基团，选自C1-C20烷基基团和C6-C20芳基基团；n代表0到3之间的整数；R2和R3代表R1或公式（2）；R2和R3中的任一或两者代表公式（2），（在公式中，X代表C2-C20烷基基团；Y代表氢原子、C1-C20烷基基团、C6-C20芳基基团、C7-C40芳基烷基基团、C1-C20烷氧基团、C6-C20芳氧基团、C7-C40芳基烷氧基团和卤素原子中的任意一种。）】
• STICK-SHAPED BASE MATERIAL COMPRISING LIPID PEPTIDE COMPOUND
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20180200173A1

  公开（公告）日：2018-07-19

  A solid base material for external use on skin that has a breaking strength sufficiently high to be usable as a stick-shaped base material or the like. A solid base material for external use on skin containing a lipid peptide compound including at least one of compound of Formula (1), the similar compound thereof and the pharmacologically usable salts thereof; water; and a 1,3-alkanediol; wherein R 1 is a C 9-23 aliphatic group; R 2 is a hydrogen atom or a C 1-4 alkyl group optionally having a C 1 or C 2 branched chain; and R 3 is a —(CH 2 ) n —X group, wherein n is a number from 1 to 4, and X is amino group, guanidino group, -CONH 2 group, or a 5-membered ring group or 6-membered ring group optionally having one to three nitrogen atoms or a fused heterocyclic group composed of the 5-membered ring and the 6-membered ring.

  一种用于外用于皮肤的固体基材料，其断裂强度足够高，可用作棒状基材料或类似物。一种用于外用于皮肤的固体基材料，包含一个脂肽化合物，其中至少包括公式（1）的化合物、类似的化合物及其药学可用的盐；水；和1,3-烷二醇；其中R1是C9-23脂肪基；R2是氢原子或C1-4烷基，可选地具有C1或C2支链；R3是—（CH2）n—X基团，其中n是1至4之间的数字，而X是氨基、鸟氨酸基、-CONH2基团或具有1至3个氮原子或由5-成员环和6-成员环组成的融合杂环基团中的5-成员环基团或6-成员环基团。
• STICK-SHAPED BASE MATERIAL HAVING HIGH WATER CONTENT
  申请人：NISSAN CHEMICAL CORPORATION

  公开号：US20200197284A1

  公开（公告）日：2020-06-25

  A stick-shaped base material capable of having a breaking strength required for a stick-shaped base material even when the amount of a lipid peptide compound contained therein is reduced, including: a surfactant; water; a lipid peptide compound including at least one of compound of the following Formula (1) and similar compound thereof or pharmaceutically usable salts of the compounds: wherein R 1 is a C 9-23 aliphatic group; R 2 is a hydrogen atom or a C 1-4 alkyl group optionally having a C 1 or C 2 branched chain; and R 3 is a —(CH 2 ) n —X group, wherein n is a number of 1 to 4, and X is an amino group, guanidine group, or a —CONH 2 group, or a 5-membered or 6-membered ring optionally having one to three nitrogen atoms or a fused heterocyclic ring composed of the rings; a 1,2-alkanediol or a 1,3-alkanediol; at least one fatty acid; and an alginic acid derivative.

  一种棒状基材料，即使其中含有脂肽化合物的量减少，仍能具有棒状基材料所需的断裂强度，包括：表面活性剂；水；脂肽化合物，其中包括以下式（1）的化合物和类似化合物或其药用盐之一：其中R1是C9-23脂肪基；R2是氢原子或C1-4烷基，可选地具有C1或C2支链；R3是—（CH2）n—X基团，其中n为1至4的数字，X是氨基、鸟氨酸基或—CONH2基团，或者是具有1至3个氮原子的5元或6元环，或者是由这些环组成的融合杂环；1,2-癸二醇或1,3-癸二醇；至少一种脂肪酸；和藻酸衍生物。
• STICK-TYPE SOLID BASE MATERIAL FOR EXTERNAL APPLICATION TO SKIN
  申请人：NISSAN CHEMICAL CORPORATION

  公开号：US20200138679A1

  公开（公告）日：2020-05-07

  A solid base material is capable of preventing “sweating” over time. A stick-type solid base material for external application to skin including a lipidic peptide compound including at least one of compounds of the following Formulae (1), the similar compounds thereof or pharmaceutically usable salts of the compounds, a surfactant, water, an oily base, and a saturated or unsaturated monohydric alcohol having a carbon atom number of 8 to 30: wherein R 1 is a C 9-23 aliphatic group; R 2 is a hydrogen atom or a C 1-4 alkyl group optionally having a C 1 or C 2 branched chain; and R 3 is a —(CH 2 ) n —X group, n is a number of 1 to 4, and X is an amino group, a guanidino group, a —CONH 2 group, or a 5-membered ring or 6-membered ring optionally having one to three nitrogen atoms or a fused heterocyclic ring composed of the 5-membered ring and the 6-membered ring.

  一种固体基材料能够防止“出汗”现象。一种用于外部涂抹于皮肤的棒状固体基材料，包括脂肪肽化合物，其中至少包括以下化合物之一，其类似化合物或化合物的药用盐，表面活性剂，水，油性基质和具有8到30个碳原子数的饱和或不饱和单醇：其中R1是C9-23脂肪基；R2是氢原子或C1-4烷基，可选地具有C1或C2支链；R3是-（CH2）n-X基团，其中n是1到4的数字，X是氨基团，鸟氨酸基团，-CONH2基团，或具有1到3个氮原子的5元环或6元环，或由5元环和6元环组成的融合杂环。
• Novel Liquid Organo Polysiloxane And Use Therefor
  申请人：Tamura Seiki

  公开号：US20140187649A1

  公开（公告）日：2014-07-03

  The present invention relates to a liquid organopolysiloxane having fluidity at a temperature of at least 100° C., having a silicon-bonded sugar alcohol-modified group, and having a crosslinked structure comprising a carbon-silicon bond in the crosslinking portion. The liquid organopolysiloxane of the present invention has excellent emulsion characteristics, imparts excellent tactile sensation, and, in particular, when compounded in an external use preparation or a cosmetic composition containing water and oil, takes advantage of the effects of water to suppress oiliness and provide a smooth, thick feeling when applied, a natural feeling to the skin with good compatibility with the skin, excellent moisturizing effects, and an excellent sensation during use without any oily stickiness.

  本发明涉及一种液态有机聚硅氧烷，其在至少100℃的温度下具有流动性，具有硅键合的糖醇修饰基团，并且具有交联结构，其中交联部分包括碳硅键。本发明的液态有机聚硅氧烷具有优异的乳化特性，赋予优异的触感，特别是当复合在含水和油的外用制剂或化妆品组合物中时，利用水的效果来抑制油腻感并提供平滑、浓厚的感觉，对皮肤具有良好的相容性和自然感觉，具有优异的保湿效果，在使用过程中没有任何油腻感。