4-phenyl-3,4-dihydro-1H-benzo[h]quinolin-2-one | 64257-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-phenyl-3,4-dihydro-1H-benzo[h]quinolin-2-one
• 英文别名: 7,8-Benz-3,4-dihydro-4-phenylcarbostyril；2-Oxo-4-phenyl-1,2,3,4-tetrahydrobenzochinolin
• CAS: 64257-24-5
• 化学式: C₁₉H₁₅NO
• 分子量: 273.334
• InChiKey: OGSPQWXKUXOADY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-phenyl-3,4-dihydro-1H-benzo[h]quinolin-2-one 在 sulfur 作用下， 反应 12.5h， 生成 4-phenylbenzo[h]quinolin-2(1H)-one
  参考文献：
  名称：

  [EN] COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY
  [FR] COMPOSES, COMPOSITIONS ET PROCEDES D'INHIBITION DE TOXICITE D'$G(A)-SYNUCLEINE

  摘要：

  公开号：

  WO2006034003A3
• 作为产物：
  描述：

  N-(1-萘基)-3-苯基丙烯酰胺 以 正己烷 、 溶剂黄146 为溶剂， 以12%的产率得到4-phenyl-3,4-dihydro-1H-benzo[h]quinolin-2-one
  参考文献：
  名称：

  Ninomiya, Ichiya; Hashimoto, Chiyomi; Kiguchi, Toshiko, Journal of the Chemical Society. Perkin transactions I, 1983, # 12, p. 2967 - 2972

  摘要：

  DOI：

文献信息

• Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity
  申请人：Lindquist Susan L.

  公开号：US20080261953A1

  公开（公告）日：2008-10-23

  Compounds and compositions are provided for treatment or amelioration of one or more symptoms of α-synuclein toxicity, α-synuclein mediated diseases or diseases in which α-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihy-dropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.

  提供了化合物和组合物，用于治疗或缓解α-突触核蛋白毒性、α-突触核蛋白介导的疾病或α-突触核蛋白纤维是疾病症状或病因的疾病中的一个或多个症状。在一种实施例中，用于组合物和方法的化合物是杂环基酰基胍、杂环基腙、二氢吡啶酮、杂环基和芳基苯乙酮以及杂环基吡唑。
• Compounds, compositions and methods of inhibiting alpha-synuclein toxicity
  申请人：Lindquist Susan L.

  公开号：US08440705B2

  公开（公告）日：2013-05-14

  Compounds and compositions are provided for treatment or amelioration of one or more symptoms of α-synuclein toxicity, α-synuclein mediated diseases or diseases in which α-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihydropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.

  提供了化合物和组合物，用于治疗或缓解α-突触核蛋白毒性、α-突触核蛋白介导的疾病或α-突触核蛋白纤维是该疾病的症状或原因的疾病的一个或多个症状。在一种实施例中，用于组合物和方法的化合物为杂环基酰基胍、杂环基肼酮、二氢吡啶酮、杂环基和芳基苯乙酮以及杂环基吡唑。
• Compounds, compositions and methods of inhibiting a-synuclein toxicity
  申请人：The Whitehead Institute for Biomedical Research

  公开号：EP2433634A2

  公开（公告）日：2012-03-28

  Compounds and compositions are provided for treatment or amelioration of one or more symptoms of a-synuclein toxicity, a-synuclein mediated diseases or diseases in which a-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihydropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.

  提供的化合物和组合物用于治疗或改善a-突触核蛋白毒性、a-突触核蛋白介导的疾病或a-突触核蛋白纤维是症状或病因的疾病的一种或多种症状。在一个实施方案中，用于组合物和方法的化合物是杂芳基酰基胍、杂芳基肼、二氢吡啶酮、杂芳基和芳基苯乙烯基酮以及杂芳基吡唑。
• The Triflic Acid-Mediated Cyclization Reactions of <i>N</i>-Cinnamoyl-1-Naphthylamines
  作者：Frank D. King、Abil E. Aliev、Stephen Caddick、Derek A. Tocher

  DOI：10.1021/jo4018827

  日期：2013.11.1

  N-Cinnamoyl-1-naphthylamines undergo a cyclization reaction with triflic acid to form 4-pheny1-3,4-dihydro-1H-naphth[1,8-bc] azepin-2- ones and 4-phenyl-3,4-dihydro-1H-benzo [It] quinolin-2-ones. However, the N-benzyl analogues also undergo a unique cascade reaction to form novel heptacyclic structures via a 1,2-addition followed by a 4-addition to the naphthalene. With an electron-rich N-benzyl substituent, the heptacycle is the sole product.
• STRODS YA. A.; LIELBRIEDIS I. EH.; NEJLAND O. YA., XIMIYA GETEROTSIKL. SOEDIN., 1977, HO 7, 977-979
  作者：STRODS YA. A.、 LIELBRIEDIS I. EH.、 NEJLAND O. YA.

  DOI：——

  日期：——