(6-chloro-2-phenylquinolin-4-yl)(piperidin-2-yl)methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (6-chloro-2-phenylquinolin-4-yl)(piperidin-2-yl)methanol
• 英文别名: NSC13097；(6-chloro-2-phenyl-[4]quinolyl)-[2]piperidyl-methanol；(6-Chlor-2-phenyl-[4]chinolyl)-[2]piperidyl-methanol；(6-Chloro-2-phenylquinolin-4-yl)-piperidin-2-ylmethanol
• 化学式: C₂₁H₂₁ClN₂O
• 分子量: 352.864
• InChiKey: YVTAGCVIOXWKOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium carbonate 作用下， 生成 (6-chloro-2-phenylquinolin-4-yl)(piperidin-2-yl)methanol
  参考文献：
  名称：

  潜在的抗疟药（氯-2-苯基喹啉基-4）-α-哌啶基甲醇。

  摘要：

  DOI：

  10.1021/ja01216a089

文献信息

• COMPOUNDS AND USE FOR TREATING CANCER
  申请人：GLIONOVA AB

  公开号：US20160214958A1

  公开（公告）日：2016-07-28

  The present invention relates to certain 2,4-disubstituted quinoline derivatives, to their therapy, as well as to pharmaceutical compositions comprising said compounds. More specifically the invention relates to certain 2,4-disubstituted quinoline derivatives or pharmaceutical compositions comprising said compounds for the treatment of cancers characterized by overactive Ras and/or Rac or signalling pathway.

  本发明涉及某些2,4-二取代喹啉衍生物及其治疗方法，以及包含该化合物的制药组合物。更具体地说，本发明涉及某些2,4-二取代喹啉衍生物或包含该化合物的制药组合物，用于治疗由过度活跃的Ras和/或Rac或信号通路所特征的癌症。
• Quninoline Methanol Compounds for the Treatment and Prevention of Parasitic Infections
  申请人：Dow Geoffrey

  公开号：US20110092488A1

  公开（公告）日：2011-04-21

  Malaria is responsible for 1-2 million deaths and 300-500 million clinical cases annually and is an ever present problem for the military, tourists and business travelers. Mefloquine is known and used for malaria prophylaxis. However it is associated with neurological effects. The present invention is directed to providing new and novel quinoline analogs that are less neurotoxic than mefloquine without compromising efficacy. The present invention is also directed to the prevention and treatment of other microbial, parasitic, protozoan, bacterial and fungal diseases.