4,4-dimethyl-1,3-diphenylpent-1-en-3-ol | 431949-52-9

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 4,4-dimethyl-1,3-diphenylpent-1-en-3-ol
• CAS: 431949-52-9
• 化学式: C₁₉H₂₂O
• 分子量: 266.383
• InChiKey: XVTCVWHOYMPOJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.63
• 重原子数：
  20.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  4,4-dimethyl-1,3-diphenylpent-1-en-3-ol 在 iron(III) chloride hexahydrate 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以90%的产率得到3-tert-butyl-1-phenylindene
  参考文献：
  名称：

  Efficient synthesis of indenes by FeCl3·6H2O-catalyzed intramolecular Friedel–Crafts reaction of aryl-substituted allylic alcohols

  摘要：

  An efficient procedure for the synthesis of substituted indenes through the FeCl3 center dot 6H(2)O-catalyzed intramolecular Friedel-Crafts cyclization of aryl-substituted allylic alcohols has been developed. This method features the easily available starting materials, cheap catalyst, simple manipulation, and mild conditions. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.070

文献信息

• Efficient synthesis of indenes by FeCl3·6H2O-catalyzed intramolecular Friedel–Crafts reaction of aryl-substituted allylic alcohols
  作者：Jialiang Wang、Lixin Zhang、Yufeng Jing、Wen Huang、Xigeng Zhou

  DOI：10.1016/j.tetlet.2009.06.070

  日期：2009.9

  An efficient procedure for the synthesis of substituted indenes through the FeCl3 center dot 6H(2)O-catalyzed intramolecular Friedel-Crafts cyclization of aryl-substituted allylic alcohols has been developed. This method features the easily available starting materials, cheap catalyst, simple manipulation, and mild conditions. (C) 2009 Elsevier Ltd. All rights reserved.