4-N-[8-[(7-chloroquinolin-4-yl)amino]octyl]-2-N-(3,5-dimethoxyphenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine | 1207449-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-N-[8-[(7-chloroquinolin-4-yl)amino]octyl]-2-N-(3,5-dimethoxyphenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine
• CAS: 1207449-60-2
• 化学式: C₃₂H₄₁ClN₈O₃
• 分子量: 621.182
• InChiKey: XNBZRAANBRNUPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  44
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  4-chloro-N-(3,5-dimethoxyphenyl)-6-(morpholin-4-yl)-1,3,5-triazin-2-amine 、 N¹-(7-chloroquinolin-4-yl)octane-1,8-diamine 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 4-N-[8-[(7-chloroquinolin-4-yl)amino]octyl]-2-N-(3,5-dimethoxyphenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine
  参考文献：
  名称：

  Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline–triazine conjugates

  摘要：

  A series of 4-aminoquinoline-triazine conjugates with different substitution pattern have been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive and resistant strains of Plasmodium falciparum. Compounds 16, 19, 28 and 35 exhibited promising antimalarial activity against both strains of P. falciparum. Cytotoxicity of these compounds was tested against three cell lines. Several compounds did not show any cytotoxicity up to a high concentration (48 mu M), others exhibited mild toxicities but selective index for antimalarial activity was high for most of these conjugates. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.106

文献信息

• Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline–triazine conjugates
  作者：Sunny Manohar、Shabana I. Khan、Diwan S. Rawat

  DOI：10.1016/j.bmcl.2009.10.106

  日期：2010.1

  A series of 4-aminoquinoline-triazine conjugates with different substitution pattern have been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive and resistant strains of Plasmodium falciparum. Compounds 16, 19, 28 and 35 exhibited promising antimalarial activity against both strains of P. falciparum. Cytotoxicity of these compounds was tested against three cell lines. Several compounds did not show any cytotoxicity up to a high concentration (48 mu M), others exhibited mild toxicities but selective index for antimalarial activity was high for most of these conjugates. (c) 2009 Elsevier Ltd. All rights reserved.