CVT 3141 | 313348-20-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: CVT 3141
• 英文别名: (4S,2R,3R,5R)-2-{6-amino-2-[4-(4-chlorophenyl)pyrazolyl]purin-9-yl}-5-(hydroxymethyl)oxolane-3,4-diol；(2R,3R,4S,5R)-2-{6-Amino-2-[4-(4-chloro-phenyl)-pyrazol-1-yl]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol；(2R,3R,4S,5R)-2-[6-amino-2-[4-(4-chlorophenyl)pyrazol-1-yl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
• CAS: 313348-20-8
• 化学式: C₁₉H₁₈ClN₇O₄
• 分子量: 443.849
• InChiKey: RCZJMXUMKREDMI-SCFUHWHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  157
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  2-肼基腺苷 、 2-(4-氯苯基)丙二醛 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 生成 CVT 3141
  参考文献：
  名称：

  Structure–affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor

  摘要：

  The structure-affinity relationships of two novel 2-substituted adenosine series containing a substituted pyrazole attached at the N-1 or C-4 position for the adenosine (ADO) A(2A) receptor are described. Compounds in the 2-(N-1-pyrazolyl) adenosine series IV provided the highest affinity for the ADO A(2A) receptor as compared to the 2-(C-4-pyrazolyl) series V. The main structural differences between the two series point to the N-1 nitrogen of series IV imparting more favorable binding interactions with the receptor than those of series V. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00609-1

文献信息

• [EN] N-PYRAZOLE A2A RECEPTOR AGONISTS<br/>[FR] AGONISTES DU RECEPTEUR A2A N-PYRAZOLE
  申请人：CV THERAPEUTICS INC

  公开号：WO2000078779A2

  公开（公告）日：2000-12-28

  2-Adenosine N-pyrazole compounds having formula (1) and methods for using compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart.

  具有式（1）的2-腺苷N-吡唑化合物，以及使用该化合物作为A2A受体激动剂刺激哺乳动物冠状动脉扩张用于治疗目的和心脏成像的方法。
• N-Pyrazole A2A Receptor Agonists
  申请人：Zablocki Jeff A.

  公开号：US20140073596A1

  公开（公告）日：2014-03-13

  2-adenosine N-pyrazole compounds having the following formula: and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart.

  具有以下式子的2-腺苷N-吡唑化合物：以及使用这些化合物作为A2A受体激动剂来刺激哺乳动物冠状动脉扩张以治疗目的和成像心脏的方法。
• N-pyrazole A2A receptor agonists
  申请人：Zablocki Jeff

  公开号：US20060052332A1

  公开（公告）日：2006-03-09

  2-adenosine N-pyrazole compounds having the following formula: and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart.

  以下是具有以下式子的2-腺苷N-吡唑化合物，并且使用这些化合物作为A2A受体激动剂来刺激哺乳动物冠状动脉扩张的治疗目的和心脏成像目的的方法： 同时，这些化合物的中文名为2-腺苷N-吡唑化合物。
• N-PYRAZOLE A2A RECEPTOR AGONISTS
  申请人：Zablocki Jeff A.

  公开号：US20110144320A1

  公开（公告）日：2011-06-16

  2-adenosine N-pyrazole compounds having the following formula: and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart.

  以下是2-腺苷N-吡唑化合物的化学式，以及使用这些化合物作为A2A受体激动剂刺激哺乳动物冠状动脉扩张以进行治疗和心脏成像的方法。
• Myocardial perfusion imaging using adenosine receptor agonists
  申请人：Gilead Palo Alto, Inc.

  公开号：EP2366396A1

  公开（公告）日：2011-09-21

  A myocardial imaging method that is accomplished by administering one or more adenosime A2A adenosine receptor agonist to a human undergoing myocardial imaging as well as pharmaceutical compositions comprising at least one A2a receptor agonist, at least one liquid carrier, and at least one co-solvent.

  一种心肌成像方法，通过向接受心肌成像的人施用一种或多种腺苷 A2A 腺苷受体激动剂以及包含至少一种 A2a 受体激动剂、至少一种液体载体和至少一种助溶剂的药物组合物来实现。