N-[2-(3-chlorophenyl)ethyl]-4-methyl-2-oxo-1H-quinoline-3-carboxamide | 1132646-65-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[2-(3-chlorophenyl)ethyl]-4-methyl-2-oxo-1H-quinoline-3-carboxamide
• CAS: 1132646-65-1
• 化学式: C₁₉H₁₇ClN₂O₂
• 分子量: 340.809
• InChiKey: ACZUGLBDXCKIBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid chloride 、 2-(3-氯苯基)乙胺 在 三乙胺 作用下， 以 丙酮 为溶剂， 生成 N-[2-(3-chlorophenyl)ethyl]-4-methyl-2-oxo-1H-quinoline-3-carboxamide
  参考文献：
  名称：

  4-羟基-2-喹诺酮类140. 4-甲基-2-氧代-1,2-二氢喹啉-3-羧酸的芳基烷基酰胺的合成和利尿活性

  摘要：

  The interaction of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid with thionyl chloride in oxygen-containing solvents leads to the formation of a significant amount of colored side products, consequently it was proposed the reaction be carried out in carbon tetrachloride. The synthesis of a series of amides was effected by the amidation of the obtained acid chloride with appropriate primary arylalkylamines. Results are presented of a study of the effect of the synthesized compounds on the urine-excreting function of the kidney.

  DOI：

  10.1007/s10593-008-0009-5

文献信息

• 4-Hydroxy-2-quinolones 140. Synthesis and diuretic activity of arylalkylamides of 4-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid
  作者：I. V. Ukrainets、N. L. Bereznyakova、V. A. Parshikov、V. N. Kravchenko

  DOI：10.1007/s10593-008-0009-5

  日期：2008.1

  The interaction of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid with thionyl chloride in oxygen-containing solvents leads to the formation of a significant amount of colored side products, consequently it was proposed the reaction be carried out in carbon tetrachloride. The synthesis of a series of amides was effected by the amidation of the obtained acid chloride with appropriate primary arylalkylamines. Results are presented of a study of the effect of the synthesized compounds on the urine-excreting function of the kidney.