4-methyl-2-oxo-N-(pyridin-3-ylmethyl)-1H-quinoline-3-carboxamide | 1132646-61-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-methyl-2-oxo-N-(pyridin-3-ylmethyl)-1H-quinoline-3-carboxamide
• CAS: 1132646-61-7
• 化学式: C₁₇H₁₅N₃O₂
• 分子量: 293.325
• InChiKey: FRPSOOAHYHBMGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氨甲基吡啶 、 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid chloride 在 三乙胺 作用下， 以 丙酮 为溶剂， 生成 4-methyl-2-oxo-N-(pyridin-3-ylmethyl)-1H-quinoline-3-carboxamide
  参考文献：
  名称：

  4-羟基-2-喹诺酮类140. 4-甲基-2-氧代-1,2-二氢喹啉-3-羧酸的芳基烷基酰胺的合成和利尿活性

  摘要：

  The interaction of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid with thionyl chloride in oxygen-containing solvents leads to the formation of a significant amount of colored side products, consequently it was proposed the reaction be carried out in carbon tetrachloride. The synthesis of a series of amides was effected by the amidation of the obtained acid chloride with appropriate primary arylalkylamines. Results are presented of a study of the effect of the synthesized compounds on the urine-excreting function of the kidney.

  DOI：

  10.1007/s10593-008-0009-5