3'-azido-2',3'-dideoxyinosine | 116597-13-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 3'-azido-2',3'-dideoxyinosine
• 英文别名: Inosine, 3'-azido-2',3'-dideoxy-；9-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• CAS: 116597-13-8
• 化学式: C₁₀H₁₁N₇O₃
• 分子量: 277.242
• InChiKey: SEUFIMAGNSSKRT-RRKCRQDMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3'-叠氮-2',3'-双脱氧腺苷 在 disodium hydrogenphosphate 、 potassium dihydrogenphosphate 作用下， 反应 1.0h， 以97%的产率得到3'-azido-2',3'-dideoxyinosine
  参考文献：
  名称：

  Anchimeric assistance of a 5'-O-carbonyl function for inversion of configuration at the 3'-carbon atom of 2'-deoxyadenosine. Synthesis of 3'-azido-2',3'-dideoxyadenosine and 3'-azido-2',3'-dideoxyinosine

  摘要：

  DOI：

  10.1021/jo00256a027

文献信息

• [EN] COMPOSITIONS AND METHODS FOR SYNTHESIS OF PHOSPHORYLATED MOLECULES<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE SYNTHÈSE DE MOLÉCULES PHOSPHORYLÉES
  申请人：UNIV CALIFORNIA

  公开号：WO2019195494A1

  公开（公告）日：2019-10-10

  The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

  这项发明提供了合成磷酸化有机化合物的组合物和方法，包括核苷三磷酸。
• Nucleotide mimics and their prodrugs
  申请人：——

  公开号：US20040059104A1

  公开（公告）日：2004-03-25

  The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.

  本发明涉及核苷二磷酸模拟物和核苷三磷酸模拟物，其中包含二磷酸或三磷酸基团模拟物，以及可选的糖修饰和/或碱基修饰。本发明的核苷酸模拟物，以药学上可接受的盐、药学上可接受的前药或药物配方的形式，可用作抗病毒、抗微生物和抗癌剂。本发明提供了一种治疗病毒感染、微生物感染和增生性疾病的方法。本发明还涉及包含本发明化合物的药物组合物，可选地与其他药理活性剂结合。
• [EN] NOVEL PHOSPH(ON)ATE- AND SULF(ON)ATE-BASED PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL AGENTS<br/>[FR] NOUVEAUX NUCLÉOSIDES MODIFIÉS AVEC UN PHOSPHATE, À BASE DE PHOSPH(ON)ATE ET DE SULF(ON)ATE, UTILES COMME SUBSTRATS POUR LES POLYMÉRASES ET COMME AGENTS ANTIVIRAUX
  申请人：UNIV LEUVEN KATH

  公开号：WO2011069688A1

  公开（公告）日：2011-06-16

  This invention provides phosphate-modified nucleosides represented by the structural formula ( I ): wherein W is O or S, and wherein B, R1; R3 and R2. are as defined herein. These compounds are useful as substrates for DNA/RNA polymerases, and as anti-viral agents in particular against HIV-1.

  这项发明提供了由结构式（I）表示的磷酸酯修饰核苷，其中W为O或S，B、R1、R3和R2的定义如本文所述。这些化合物可作为DNA/RNA聚合酶的底物使用，特别是作为抗HIV-1的抗病毒药物。
• NOVEL PHOSPH(ON)ATE- AND SULF(ON)ATE-BASED PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL AGENTS
  申请人：Herdewijn Piet

  公开号：US20120245029A1

  公开（公告）日：2012-09-27

  This invention provides phosphate-modified nucleosides represented by the structural formula (I): wherein W is O or S, and wherein B, R 1 ; R 3 and R 2 . are as defined herein. These compounds are useful as substrates for DNA/RNA polymerases, and as anti-viral agents in particular against HIV-1.

  这项发明提供了由结构式(I)表示的磷酸修饰核苷酸，其中W为O或S，而B、R1、R2和R3如此处所定义。这些化合物可作为DNA/RNA聚合酶的底物，特别是在抗击HIV-1方面作为抗病毒剂。
• Use of 3'-fluro-3' deoxythymidine for the manufacture of a medicament for the treatment of virus infections
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP0286825A2

  公开（公告）日：1988-10-19

  A method of treating viral diseases in a human subject is disclosed. The method involves applying effective amounts of the compound: wherein X is an azido group, a methoxy radical or a fluorine atom and B is thymine, uracil, guanine, cytosine, purine or hypoxanthine if X is methoxy or fluorine, and B is guanine, purine or hypoxanthine if X is azido or a pharmaceutically acceptable salt thereof. Also disclosed are compositions and compounds useful in the method.

  本发明公开了一种治疗人类病毒性疾病的方法。该方法包括应用有效量的化合物： 其中 X 是叠氮基、甲氧基或氟原子，如果 X 是甲氧基或氟原子，则 B 是胸腺嘧啶、尿嘧啶、鸟嘌呤、胞嘧啶、嘌呤或次黄嘌呤；如果 X 是叠氮基，则 B 是鸟嘌呤、嘌呤或次黄嘌呤或其药学上可接受的盐。还公开了用于该方法的组合物和化合物。