9-羟基甲基-10-甲基蒽 | 71339-55-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 9-羟基甲基-10-甲基蒽
• 中文别名: 辅酶A,S-(2-溴辛酸酯)(9CI)
• 英文名称: 9-(hydroxymethyl)-10-dimethylanthracene
• 英文别名: 9-(hydroxymethyl)-10-methylanthracene；9-(10-Methylanthracene)methanol；10-methyl-9-anthracenemethanol；(10-Methyl-[9]anthryl)-methanol；10-Methyl-9-hydroxy-methyl-anthracen；9-hydroxymethyl-10-methylanthracene；(10-methylanthracen-9-yl)methanol
• CAS: 71339-55-4
• 化学式: C₁₆H₁₄O
• 分子量: 222.287
• InChiKey: IIJAEVGPROJHIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-羟基甲基-10-甲基蒽 在 N-溴代丁二酰亚胺(NBS) 、 氢溴酸 、 过氧化苯甲酰 作用下， 生成 9,10-二(溴甲基)蒽
  参考文献：
  名称：

  混合双功能。4.多环芳烃的烷基化衍生物的抗肿瘤活性作为结构和载体的函数。

  摘要：

  DOI：

  10.1021/jm00271a018
• 作为产物：
  描述：

  cis-9,10-dihydro-anthracene-9,10-dicarboxylic acid dimethyl ester 在 氢氧化钾 、 lithium aluminium tetrahydride 、 异戊醇 作用下， 生成 9-羟基甲基-10-甲基蒽
  参考文献：
  名称：

  Tardieu, Annales de Chimie (Cachan, France), 1961, vol. <13> 6, p. 1445,1495

  摘要：

  DOI：

文献信息

• Parallel Synthesis and Purification Using Anthracene-Tagged Substrates
  作者：Xiang Wang、John J. Parlow、John A. Porco

  DOI：10.1021/ol0065625

  日期：2000.11.1

  [reaction: see text] A new strategy for the synthesis and purification of synthetic intermediates is described using anthracene-tagged ester substrates in conjunction with an N-benzylmaleimide resin. Anthracene chemical tags permit use of standard solution-phase reaction conditions and reaction-monitoring techniques.

  [反应：见正文]描述了一种使用蒽标记的酯底物与N-苄基马来酰亚胺树脂结合来合成和纯化合成中间体的新策略。蒽化学标签允许使用标准溶液相反应条件和反应监测技术。
• PHOTOBASE GENERATOR
  申请人：Kuramoto Ayako

  公开号：US20110233048A1

  公开（公告）日：2011-09-29

  There is intended to provide the novel compounds which generate a base easily when irradiated with long wavelength light (active energy rays), a photobase generator containing the compounds and a photobase generation method, and the present invention relates to the compounds represented by the general formula [1], a photobase generator containing the compounds and a photobase generation method: (wherein, Ar represents any of groups with specific structures selected from the group consisting of an anthracenyl group, an anthraquinonyl group and a pyrenyl group; R 1 and R 2 each independently represent a hydrogen atom or a linear, branched or cyclic alkyl group having 1 to 10 carbon atoms, or represent ones which can form an alicyclic ring containing nitrogen atom(s) or an aromatic ring containing nitrogen atom(s) together with a nitrogen atom to which they are bound, which the rings having 3 to 8 carbon atoms which may have a substituent, R 3 and R 4 each independently represent a hydrogen atom, a linear, branched or acyclic alkyl group having 1 to 10 carbon atoms).

  本发明旨在提供当受长波长光（活性能量射线）照射时易于产生碱的新化合物，包含这些化合物的光碱发生器以及光碱生成方法，本发明涉及由通式[1]表示的化合物，包含这些化合物的光碱发生器以及光碱生成方法：（其中，Ar代表从蒽基团、蒽醌基团和芘基团中选择的具有特定结构的任何基团；R1和R2各自独立地代表氢原子或具有1至10个碳原子的直链、支链或环烷基基团，或表示能够与它们结合的氮原子形成含氮原子的脂环烷基环或含氮原子的芳香环，这些环具有3至8个碳原子，可能有取代基；R3和R4各自独立地代表氢原子，具有1至10个碳原子的直链、支链或非环烷基基团）。
• Synthesis and transformations of a few 9-(pent-4-yn-1-yl)anthracene-type systems
  作者：Eason M. Mathew、Tomson Devassia、Sreedharan Prathapan、Perupparampil A. Unnikrishnan

  DOI：10.24820/ark.5550190.p010.637

  日期：——

  9-(Pent-4-yn-1-yl)anthracene-type compounds can potentially undergo intramolecular Diels-Alder (IMDA) reaction to form 9,11-annulated dibenzobarrelenes. Herein we report the synthesis and IMDA reactions of several heteroatom incorporated 9-(pent-4-yn-1-yl)anthracene-type compounds.

  9-(Pent-4-yn-1-yl) 蒽类化合物可能会发生分子内狄尔斯-阿尔德 (IMDA) 反应以形成 9,11-环化二苯并二甲苯。在此，我们报告了几种掺入杂原子的 9-(pent-4-yn-1-yl) 蒽类化合物的合成和 IMDA 反应。
• Antigenic GM-CSF peptides and antibodies to GM-CSF
  申请人：Morphotek, Inc.

  公开号：US10023632B2

  公开（公告）日：2018-07-17

  Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided. The antibodies may be used in therapeutic methods, for example in the treatment of cancer, infectious disease, or autoimmune disease.

  提供了能分泌具有高结合特异性和生物活性（特别是对粒细胞-巨噬细胞集落刺激因子的中和活性）的人类单克隆抗体的杂交瘤系，以及产生杂交瘤系的方法。还提供了目标抗原和表位。这些抗体可用于治疗方法，例如治疗癌症、传染病或自身免疫性疾病。
• Methods for generating antibiotic resistant microbes and novel antibiotics
  申请人：——

  公开号：US20030068808A1

  公开（公告）日：2003-04-10

  The invention provides methods for generating antibiotic resistant bacteria comprising blocking mismatch repair in a bacterium to make hypermutable bacteria, contacting the bacteria with at least one antibiotic, selecting bacteria that are resistant to the antibiotic, and culturing the antibiotic resistant bacteria. The invention also provides methods of determining the genes responsible for antibiotic resistance.

  本发明提供了产生抗生素耐药细菌的方法，包括阻断细菌中的错配修复以制造高耐药细菌，使细菌与至少一种抗生素接触，选择对抗生素耐药的细菌，培养抗生素耐药细菌。本发明还提供了确定抗生素耐药性基因的方法。